1036959-23-5

Basic information

• Product Name: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)
• Synonyms: Vildagliptin IMpurity 2 (Mixture of DiastereoMers);Vildagliptin IMpurity 2;Vildagliptin IMPURITY B;(2S)-1-{[{2[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}[(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]]acetyl}pyrrolidine-2-carbonitrile;Vildagliptin Impurity 1;(2S)-1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile;(2S,2'S)-1,1'-(2,2'-((3-hydroxyadamantan-1-yl)azanediyl)bis(acetyl))bis(pyrrolidine-2-carbonitrile)
• CAS NO: 1036959-23-5
• Molecular Formula: C₂₄H₃₃N₅O₃
• Molecular Weight: 439.55052
• Mol File: 1036959-23-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 730.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 14.99±0.40(Predicted)
• CAS DataBase Reference: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)(CAS DataBase Reference)
• NIST Chemistry Reference: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)(1036959-23-5)
• EPA Substance Registry System: Vildagliptin IMpurity 2 (Mixture of DiastereoMers)(1036959-23-5)

Safety Data

• Hazardous Substances Data: 1036959-23-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1036959-23-5 differently. You can refer to the following data:
1. (2S,2'S)-1,1'-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile is an impurity of Vildagliptin which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).
2. (2S,2''S)-1,1''-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]bis-2-pyrrolidinecarbonitrile is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).

Upstream product

• 23500-10-9 (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid 
• 147-85-3 L-proline 
• 702-82-9 3-aminoadamantan-1-ol 
• 207557-35-5 (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 

Relevant articles and documents

2 - substituted pyrrolidines compound, preparation method and its application in the preparation of the peculiar smell (by machine translation)

The invention discloses a 2 - substituted pyrrolidines compound, preparation method and its application in the preparation of the peculiar smell, the tetrahydro-pyrrole derivatives of formula (I) has the structure as illustrated, using the intermediate synthesis when the peculiar smell, the preparation method of the original source of auxiliary materials are cheap and easily obtained, the process route is short, low cost, mild conditions in the reaction process of the security, without the special requirements of the device, can be suitable for industrial production. (by machine translation)