207557-35-5Relevant articles and documents
Synthesis of main impurity of vildagliptin
Tao, Zhu,Deng, Yu,Chen, Yingjie,Wang, Anmin,Hu, Xiangnan
, p. 3489 - 3492 (2014)
A four-step synthesis of the main impurity of vildagliptin has been easily accomplished with high-yielding starting from L-proline. This compound can be used as a reference marker in an analytical method to determine the chemical purity of the vildagliptin.
PROCESS FOR THE PREPARATION OF VILDAGLIPTIN
-
Page/Page column 7; 8, (2021/06/22)
The present invention relates to process for the preparation of Vildagliptin. The present invention involves an ecologically friendly process by avoiding the dehydrating agent and use of reagents that are less expensive, easier to handle and its cost effective industrial applicable process.
PYRROLIDINE AND PIPERIDINE COMPOUNDS
-
Paragraph 0250-0251, (2021/05/15)
The present technology provides pyrrolidine and piperidine compounds or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. In particular, said compounds may be usefully applied in the treatment and prevention of FAP-mediated diseases.
Production method of vildagliptin
-
, (2021/10/27)
and Alkali metal bromides are in vildagliptin or a salt thereof. Use of a crystal form, a deuterated substance, a tritium substitute, and a solvate as a catalyst. The vildagliptin product produced by the method is high in purity and low in impurity content, particularly the product quality control of the vildagliptin bulk drug and/or the pharmaceutical preparation is facilitated. Moreover, the reaction condition is mild, operation and control are convenient, the yield is high, the energy consumption is low, the cost is low, and the method is suitable for industrial production and popularization and application.