10488-39-8

Basic information

• Product Name: 1-DescarbaMoxy-2-carbaMoxy MethocarbaMol
• Synonyms: 1-DescarbaMoxy-2-carbaMoxy MethocarbaMol;1-(HydroxyMethyl)-2-(o-Methoxyphenoxy)carbaMic Acid Ethyl Ester;1-DescarbaMoyl-2-carbaMoyl MethocarbaMol;3-(2-Methoxyphenoxy)-1,2-propanediol 2-CarbaMate
• CAS NO: 10488-39-8
• Molecular Formula: C₁₁H₁₅NO₅
• Molecular Weight: 241.2405
• Product Categories: Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 10488-39-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 117-119 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 450.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.01±0.50(Predicted)
• CAS DataBase Reference: 1-DescarbaMoxy-2-carbaMoxy MethocarbaMol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-DescarbaMoxy-2-carbaMoxy MethocarbaMol(10488-39-8)
• EPA Substance Registry System: 1-DescarbaMoxy-2-carbaMoxy MethocarbaMol(10488-39-8)

Safety Data

• Hazardous Substances Data: 10488-39-8(Hazardous Substances Data)

Usage

Description

1-DescarbaMoxy-2-carbaMoxy MethocarbaMol is an impurity derived from Methocarbamol, a muscle relaxant. It possesses inhibitory effects on lysosomal acid lipase, a key enzyme involved in lipid metabolism.

Uses

Used in Pharmaceutical Industry:
1-DescarbaMoxy-2-carbaMoxy MethocarbaMol is used as a potential therapeutic agent for conditions related to lipid metabolism dysfunction. Its inhibitory effects on lysosomal acid lipase make it a promising candidate for the development of treatments targeting lipid storage disorders and other related conditions.
Used in Research Applications:
In the field of research, 1-DescarbaMoxy-2-carbaMoxy MethocarbaMol can be utilized as a tool compound to study the role of lysosomal acid lipase in cellular processes and its potential as a therapeutic target for various diseases. This may include investigations into the underlying mechanisms of lipid metabolism and the development of novel drug delivery systems to enhance the bioavailability and efficacy of this compound.

Upstream product

• 93728-27-9 1-benzyloxy-3-(2-methoxy-phenoxy)-propan-2-ol 
• 2049-22-1 2-carbamoyloxy-1-chloro-3-(2-methoxy-phenoxy)-propane 
• 2049-21-0 rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one 
• 7664-41-7 ammonia 
• 67-63-0 isopropyl alcohol 
• 92042-73-4 1-Acetoxy-2-carbaminoyloxy-3-(2-methoxy-phenoxy)-propan 
• 93950-95-9 1-benzyloxy-2-carbamoyloxy-3-(2-methoxy-phenoxy)-propane 
• 532-03-6 methocarbamol 

Downstream Products

• 532-03-6 methocarbamol 
• 2049-22-1 2-carbamoyloxy-1-chloro-3-(2-methoxy-phenoxy)-propane 
• 2049-21-0 rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one 
• 92042-73-4 1-Acetoxy-2-carbaminoyloxy-3-(2-methoxy-phenoxy)-propan 

Relevant articles and documents

Methocarbamol degradation in aqueous solution

The kinetics of the hydrolysis of methocarbamol to the corresponding diol guaifenesin in aqueous solution was studied. Methocarbamol was rather stable in acidic media but easily hydrolyzed in alkaline solution. The formation of an unknown compound, proved to be an isomer of methocarbamol [the 3-(2- methoxyphenoxy)-propanediol 2-carbamate] is involved. The amounts of methocarbamol and the two degradation products resulting from storage of methocarbamol in various buffer solutions over a pH range of 8.0 to 10.0 at 70-80 °C (ionic strength, 0.5 M), were followed as a function of time by a reversed-phase HPLC stability-indicating method to clarify the degradation pathway of methocarbamol in alkaline solutions. Analysis of the concentration-time profiles reveals that base-catalyzed methocarbamol hydrolysis proceeded mainly through the formation of its isomer. The observed degradation rates followed approximately pseudo-first-order kinetics at constant pH and temperature.