10532-64-6

Basic information

• Product Name: Cyanamide, (4-methylphenyl)-
• CAS NO: 10532-64-6
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Mol File: 10532-64-6.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: Cyanamide, (4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyanamide, (4-methylphenyl)-(10532-64-6)
• EPA Substance Registry System: Cyanamide, (4-methylphenyl)-(10532-64-6)

Safety Data

• Hazardous Substances Data: 10532-64-6(Hazardous Substances Data)

Upstream product

• 622-52-6 p-methylphenylthiourea 
• 506-68-3 bromocyane 
• 106-49-0 p-toluidine 
• 506-77-4 cyanogen chloride 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 13036-91-4 ammonium (4-methylphenyl)carbamodithioate 
• 622-58-2 p-Tolylisocyanate 
• 19227-13-5 p-toluamidoxime 
• 104-85-8 para-methylbenzonitrile 
• 420-04-2 CYANAMID 
• 624-31-7 4-tolyl iodide 
• 6281-61-4 1-benzoyl-3-(4-methylphenyl)thiourea 
• 536-74-3 phenylacetylene 
• 4440-01-1 lithium phenylacetylide 

Downstream Products

• 103-89-9 4-Methylacetanilide 
• 55305-44-7 N-(4-Methylphenyl)-N-benzoylcyanamid 
• 54116-98-2 N,N'-di-p-tolyl guanidine 
• 17813-47-7 N,N-dimethyl-N'-p-tolyl-guanidine 
• 127213-68-7 N-phenyl-N'-p-tolyl-guanidine 
• 100253-43-8 O-ethyl-N-p-tolyl-N-vinyl-isourea 
• 3515-00-2 Kohlensaeure-<4-nitro-phenylester>-imid- 
• 56014-24-5 1,N²-diphenyl-N⁶-p-tolyl-1,5(7)-dihydro-4λ⁴-[1,2,4]thiadiazolo[5,1-e][1,2,4]thiadiazole-2,6-diamine 
• 56014-11-0 1,N,N'-tri-p-tolyl-1,5(7)-dihydro-4λ⁴-[1,2,4]thiadiazolo[5,1-e][1,2,4]thiadiazole-2,6-diamine 
• 3305-88-2 Kohlensaeure-<β.β.β-trichlor-aethylester>-imid- 
• 3515-01-3 Kohlensaeure-<3-chlor-phenylester>-imid- 
• 3305-99-5 (4-oxo-4H-benzo[e][1,3]oxazin-2-yl)-p-tolyl-cyanamide 
• 3514-98-5 Kohlensaeure-<4-acetyl-phenylester>-imid- 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.