105414-01-5

Basic information

• Product Name: Cbz-L-Pro-OCO₂-i-Bu
• CAS NO: 105414-01-5
• Molecular Weight: 349.384
• Mol File: 105414-01-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Cbz-L-Pro-OCO₂-i-Bu(CAS DataBase Reference)
• NIST Chemistry Reference: Cbz-L-Pro-OCO₂-i-Bu(105414-01-5)
• EPA Substance Registry System: Cbz-L-Pro-OCO₂-i-Bu(105414-01-5)

Safety Data

• Hazardous Substances Data: 105414-01-5(Hazardous Substances Data)

Upstream product

• 108-23-6 isopropyl chloroformate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 501-53-1 benzyl chloroformate 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 132168-73-1 Ac-Pro-D-Phe-NHMe 
• 23631-72-3 N-carbobenzoxy-L-prolyl-L-phenylalanine methyl ester 
• 54793-80-5 (S)-proline-(S)-phenylalanine methyl ester 
• 60242-12-8 C₂₂H₂₄N₂O₅ 
• 6686-03-9 (S)-benzyl 2-(((S)-3-(1H-indol-3-yl)-1-methoxy-1-oxopropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate 
• 17350-17-3 (S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-3-phenylpropanoic acid 
• 1035279-38-9 C₃₃H₄₃N₅O₅ 
• 1035278-84-2 C₂₈H₃₅N₅O₃ 
• 1035279-34-5 C₂₅H₂₃N₃O₂ 
• 1035278-87-5 (S)-benzyl 2-(8-phenylimidazo[1,2-a]pyridin-2-yl)pyrrolidine-1-carboxylate 
• 1035279-32-3 C₁₉H₁₈BrN₃O₂ 
• 1035279-41-4 (S)-benzyl-2-(8-bromoimidazo[1,2-a]pyridin-2-yl)pyrrolidine-1-carboxylate 
• 1035279-36-7 C₁₇H₁₇N₃ 
• 223785-66-8 2-(S)-(2-bromo-1-oxoethyl)pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Efficient ball-mill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water

The organocatalytic activity of (S)-proline-based dipeptides 1a-c has been evaluated in the asymmetric aldol reaction between representative ketones with various aromatic aldehydes under solvent-free conditions in a ball mill. In particular, the methyl ester of (S)-proline-(S)-tryptophan, (S,S)-1c, proved to be an efficient organocatalyst, and the aldol reaction proceeded with good chemical yields and excellent diastereo- and enantioselectivity (up to 98:2 anti/syn dr and up to 98% ee), in the presence of water, and 5 mol % of benzoic acid as additive.

A chiral amino-naphthalene-derived prolinamide catalyst for the enantioselective Michael addition of ketones to nitroolefins

An enantioselective Michael addition of ketones to nitroolefins has been accomplished using a novel chiral aminonaphthalenederived prolinamides catalyst 1. The desired Michael adducts were obtained in high yields (up to 93%) as well as good diastereoselectivities (>99:1) and enantioselectivities (48%-99% ee).

Reduction of ethanethiol esters to aldehydes

Reduction of ethanethiol esters of α-amino acids to α-amino aldehydes by triethylsilane and catalytic palladium-on-carbon is described. α-Amino aldehydes with Boc, Cbz, or Fmoc protection could be obtained without racemization in high yield.