105880-10-2

Basic information

• Product Name: (1R,4S)-4-{(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-1-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl]pentane-1,4-diol (non-preferred name)
• CAS NO: 105880-10-2
• Molecular Formula: C₃₀H₅₃BrO₇
• Molecular Weight: 605.6416
• Mol File: 105880-10-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 649.7°C at 760 mmHg
• Flash Point: 346.7°C
• Density: 1.223g/cm³
• Vapor Pressure: 1.26E-19mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: (1R,4S)-4-{(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-1-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl]pentane-1,4-diol (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4S)-4-{(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-1-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl]pentane-1,4-diol (non-preferred name)(105880-10-2)
• EPA Substance Registry System: (1R,4S)-4-{(2R,4aR,6R,8aS)-6-[(2S,5R)-5-bromo-2,6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-1-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl]pentane-1,4-diol (non-preferred name)(105880-10-2)

Safety Data

• Hazardous Substances Data: 105880-10-2(Hazardous Substances Data)

Upstream product

• 93395-13-2 (R)-3-{2-[(2R,4aS,6S,8aR)-6-((2R,5S)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-oxiranyl}-1-[(2R,5R)-5-(1-hydroxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-propan-1-ol 
• 119840-68-5 (2R,4aR,6R,8aS)-Octahydro-3-<(1S,4R)-4-<(2R,5S)-tetrahydro-2-methyl-5-<1-methyl-1-<<2-(trimethylsilyl)ethoxy>methoxy>ethyl>furan-2-yl>-4-hydroxy-1-(methoxymethoxy)butyl>-6-<(S)-1-(methoxymethoxy)-1,5-dimethylhex-4-enyl>-8a-methylpyrano<3,2-b>pyran 
• 121693-58-1 (2R,4aR,6R,8aS)-6-((2S,5R)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-carbonitrile 
• 121786-71-8 (2R,3R)-3-Benzyloxymethyl-2-methyl-2-(4-methyl-pent-3-enyl)-oxirane 
• 119840-68-5 (S)-4-Methoxymethoxy-4-[(2R,4aR,6R,8aS)-6-((S)-1-methoxymethoxy-1,5-dimethyl-hex-4-enyl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-1-{(R)-2-methyl-5-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-tetrahydro-furan-2-yl}-pentan-1-ol 
• 121693-65-0 1-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-3-((1S,2R,7R)-1,6,6-trimethyl-3,5,10-trioxa-bicyclo[5.2.1]dec-2-yl)-propan-1-one 
• 121710-06-3 (R)-1-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-3-((1S,2R,7R)-1,6,6-trimethyl-3,5,10-trioxa-bicyclo[5.2.1]dec-2-yl)-propan-1-ol 
• 121693-61-6 2-[(2R,5S)-5-((R)-2-Benzyloxy-1-hydroxy-ethyl)-5-methyl-tetrahydro-furan-2-yl]-propan-2-ol 
• 121693-60-5 (2R,3S)-1-Benzyloxy-3,7-dimethyl-oct-6-ene-2,3-diol 
• 121693-72-9 (1S,2S,7R)-1,6,6-Trimethyl-3,5,10-trioxa-bicyclo[5.2.1]decane-2-carbaldehyde 
• 121693-63-8 (1S,2R,7R)-1,6,6-Trimethyl-2-vinyl-3,5,10-trioxa-bicyclo[5.2.1]decane 
• 121693-64-9 (1S,2R,7R)-2-(2-Bromo-ethyl)-1,6,6-trimethyl-3,5,10-trioxa-bicyclo[5.2.1]decane 
• 121693-73-0 2-((1S,2R,7R)-1,6,6-Trimethyl-3,5,10-trioxa-bicyclo[5.2.1]dec-2-yl)-ethanol 
• 121693-71-8 ((1S,2R,7R)-1,6,6-Trimethyl-3,5,10-trioxa-bicyclo[5.2.1]dec-2-yl)-methanol 

Downstream Products

• 66873-47-0 Acetic acid (1R,4S)-4-[(4aS,6S,8aR)-6-((2R,5S)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-hydroxy-1-[(2R,5R)-5-(1-hydroxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-pentyl ester 
• 66873-47-0 thyrsiferyl 18-acetate 
• 66873-47-0 thyrsiferol monoacetate 

Relevant articles and documents

Teurilene and thyrsiferyl 23-acetate, meso and remarkably cytotoxic compounds from the marine red alga Laurencia obtusa (Hudson) Lamouroux

Two new cyclic ethers consisting of a squalene carbon skeleton have been isolated from the red alga L. obtusa. The absolute stereostructure of teurilene was elucidated by the X-ray crystallographic method, and the structure of thyrsiferyl 23-acetate was established from spectral and chemical evidence.

Total synthesis of thyrsiferyl 23-acetate, a specific inhibitor of protein phosphatase 2A and an anti-leukemic inducer of apoptosis

A convergent synthetic entry to the squalenoid polyether system has been developed and applied to the biologically active marine natural products thyrsiferyl 23-acetate (1a), thyrsiferol (1b), thyrsiferyl 18-acetate (1c), and thyrsiferyl 18,23-diacetate (

Total synthesis of (+)-thyrsiferol and (+)-venustatriol

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