107033-47-6Relevant articles and documents
An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity
Baker, James R.,Hothersall, J. Daniel,Fitzmaurice, Richard J.,Tucknott, Matthew,Vinter, Andy,Tinker, Andrew,Caddick, Stephen
supporting information; experimental part, p. 3953 - 3954 (2010/08/13)
A highly efficient, practical and flexible two-step asymmetric synthesis of the β2-selective β-blocker ICI 118,551 is reported, allowing an unambiguous determination of the dependency of biological activity with optical activity, revealing the S,S-enantiomer to be the most potent.
Halocyclization of Unsaturated Alcohols and Carboxylic Acids Using Bis(sym-collidine)iodine(I) Perchlorate
Evans, Robert D.,Magee, Joseph W.,Schauble, J. Herman
, p. 862 - 868 (2007/10/02)
Reaction of I(collidine)2(1+) ClO4(1-) with unsaturated alcohols and carboxylic acids in dichloromethane at ambient temperature has afforded three- to seven-membered-ring iodoethers and four- to seven-membered-ring iodolactones, respectively, in moderate