107469-25-0

Basic information

• Product Name: 2-amino-6-methylphenylacetaldehyde ethylene acetal
• Synonyms: 2-amino-6-methylphenylacetaldehyde ethylene acetal
• CAS NO: 107469-25-0
• Molecular Weight: 193.246
• Mol File: 107469-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-6-methylphenylacetaldehyde ethylene acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-methylphenylacetaldehyde ethylene acetal(107469-25-0)
• EPA Substance Registry System: 2-amino-6-methylphenylacetaldehyde ethylene acetal(107469-25-0)

Safety Data

• Hazardous Substances Data: 107469-25-0(Hazardous Substances Data)

Upstream product

• 107469-22-7 6-methyl-2-nitro-1-[2-(trimethylsilyl)ethynyl]-benzene 
• 107469-23-8 2-(2-ethoxyethenyl)-3-methylnitrobenzene 
• 41085-43-2 2-bromo-3-nitrotoluene 
• 107469-24-9 2-methyl-6-nitrophenylacetaldehyde ethylene acetal 

Downstream Products

• 16096-32-5 4-methyl-1H-indole 

Relevant articles and documents

Condensed Heteroaromatic Ring Systems. VI. Synthesis of Indoles and Pyrrolopyridines from o-Nitroarylacetylenes

Catalytic hydrogenation of o-nitrophenylacetaldehyde diethyl acetal over palladium-carbon, followed by intramolecular cyclization of the resulting o-aminophenylacetaldehyde diethyl acetal with hydrochloric acid, gave indole.Similarly, 4-methylindole, ethyl 5-indolecarboxylate, and various pyrrolopyridines were synthesized from the corresponding o-nitroarylacetaldehyde derivatives.The preparation of the desired o-nitroarylacetaldehydes was accomplished by the condensation of o-halonitroaromatics with trimethylsilylacetylene in the presence of dichloro-bis(triphenylphosphine)palladium as a catalyst, followed by ethanolysis of the resulting o-(trimethylsilylethenyl)nitroaromatics.Keywords - o-halonitroaromatic; o-cyanohaloaromatic; trimethylsilylacetylene; palladium-catalyzed reaction; cyclization; indole; pyrrolopyridine