1075-21-4

Basic information

• Product Name: 5-PHENYLISOTHIAZOLE
• Synonyms: 5-PHENYLISOTHIAZOLE
• CAS NO: 1075-21-4
• Molecular Formula: C₉H₇NS
• Molecular Weight: 161.22
• Mol File: 1075-21-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 201.9 °C at 760 mmHg
• Flash Point: 71.9 °C
• Appearance: /
• Density: 1.173 g/cm³
• CAS DataBase Reference: 5-PHENYLISOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYLISOTHIAZOLE(1075-21-4)
• EPA Substance Registry System: 5-PHENYLISOTHIAZOLE(1075-21-4)

Safety Data

• Hazardous Substances Data: 1075-21-4(Hazardous Substances Data)

Usage

General Description

5-Phenylisothiazole is a chemical compound with the molecular formula C9H7NS. It is a heterocyclic compound containing a five-membered ring with a nitrogen and sulfur atom. Its structure consists of a phenyl group attached to the isothiazole ring. 5-Phenylisothiazole is commonly used as a building block and intermediate in organic synthesis, particularly in the pharmaceutical industry for the production of various pharmaceuticals. It has also been studied for its potential biological activities, including antimicrobial and antifungal properties. Additionally, it has been investigated for its potential use in the development of novel materials and organic electronic devices due to its unique structure and properties.

Upstream product

• 33603-87-1 β-chlorocinnamaldehyde 
• 33603-87-1 (Z)-3-chloro-3-phenyl-2-propenal 
• 39812-71-0 3-chloro-3-phenyl-1-prop-2-en-1-yliden-dimethyliminium perchlorate 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 136809-07-9 1-tert-butyl-4-phenyl-1-aza-1,3-butadiene 
• 24301-15-3 β-N,N-dimethylaminovinyl phenyl thioketone 
• 1826-11-5 2-phenylthiazole 
• 119858-08-1 3-phenyl-3-thiocyanatoacrylaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 18712-05-5 2-methyl-3-methylthio-5-phenylisothiazolium iodide 
• 97148-34-0 2-Benzoyl-4,7,7-triphenyl-3-thia-1-aza-bicyclo[4.2.0]oct-4-en-8-one 
• 97148-37-3 2-Benzoyl-7-chloro-4-phenyl-3-thia-1-aza-bicyclo[4.2.0]oct-4-en-8-one 
• 97148-29-3 Phenyl-(6-phenyl-2H-[1,3]thiazin-2-yl)-methanone 
• 119871-51-1 5-Phenyl-2-(N-phenylcarbamoyl)-1,2-thiazol-3-on-1,1-dioxid 
• 119871-52-2 3-(Dimethylamino)-5-phenyl-1,2-thiazol-1,1-dioxid 
• 284680-73-5 4-deuterio-5-phenylisothiazole 
• 284680-72-4 4-bromo-5-phenylisothiazole 
• 1826-13-7 5-phenylthiazole 
• 1826-12-6 4-phenyl-thiazole 
• 10514-34-8 3-phenylisothiazole 
• 97148-23-7 3,6,6-Triphenyl-2-thia-1-aza-bicyclo[3.2.0]hept-3-en-7-one 
• 95117-68-3 5-phenylisothiazol-3(2H)-one-1,1-dioxide 
• 30162-68-6 2-methyl-5-phenyl-4-isothiazolin-3-thione 

Relevant articles and documents

MTA-Cooperative PRMT5 Inhibitors

The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

SULFUR DICHLORIDE AS A SULFUR TRANSFER REAGENT IN HETEROCYCLIC SYNTHESIS

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THERMOLYSIS OF 1,3-DITHIOL-2-YL AZIDES AND THERMAL PROPERTIES OF THE RESULTING 1,4,2-DITHIAZINES

2-Substituted 1,3-dithiol-2-yl azides, on thermolysis in refluxing toluene, give 3-substituted 1,4,2-dithiazines wich thermally extrude sulfur atom of the 4-position selectively to yield 3-substituted isothiazoles, while 2-unsubstituted 1,3-dithiol-2-yl azides undergo both ring expansion yielding 1,4,2-dithiazines and peculiar thermal dissociation into 1,3-dithiol-2-ylidene carbenes and hydrogen azide.