108-13-4 Usage
Description
Malonamide is a dicarboxylic acid diamide that is malonic acid in which both carboxy groups have been replaced by carbamoyl groups. It is functionally related to a malonic acid.
Chemical Properties
White crystalline powder
Uses
Different sources of media describe the Uses of 108-13-4 differently. You can refer to the following data:
1. Malonamide is used in the synthesis of malonamic acid, malonamate and malonamide derivative of some heterocyclic compounds with antiinflammatory activity.
2. Malonamide is a reagent for fluorimetric determination of reducing carbohydrates. The malonamide-based ionic liquid extractant was used in the extraction of europium(iii) and other trivalent rare earth elements from nitric acid medium.
3. The malonamide-based ionic liquid extractant was used in the
extraction of europium(iii) and other trivalent rare-earth ions from
nitric acid medium.
General Description
The malonamide derivatives are obtained by the one-pot, five-component condensation reaction of isocyanide, Meldrum′s acid, arylidene malononitrile, and two amine molecules in CH2Cl2.
Hazard
Mildly toxic by ingestion.
Synthesis
The synthesis of?Malonamide is as follows:A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), CuII-4 ? (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h.
Purification Methods
Crystallise the amide from water. [Beilstein 2 IV 1887.]
Check Digit Verification of cas no
The CAS Registry Mumber 108-13-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 108-13:
(5*1)+(4*0)+(3*8)+(2*1)+(1*3)=34
34 % 10 = 4
So 108-13-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H6N2O2/c4-2(6)1-3(5)7/h1H2,(H2,4,6)(H2,5,7)
108-13-4Relevant articles and documents
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Lemons et al.
, p. 467 (1942)
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Transfer Hydration of Dinitriles to Dicarboxamides
Naka, Hiroshi,Naraoka, Asuka
, p. 1977 - 1980 (2019)
We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1, n -dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.
Corresponding amine nitrile and method of manufacturing thereof
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Paragraph 0124; 0125; 0127, (2018/05/24)
The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.
Corresponding amine nitrile and method of manufacturing thereof
-
Paragraph 0125; 0126; 0127; 0128, (2018/07/15)
The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.