108832-15-1

Basic information

• Product Name: 2,4-DICHLORO-3-PHENYLQUINOLINE
• Synonyms: 2,4-DICHLORO-3-PHENYLQUINOLINE;AURORA KA-3179
• CAS NO: 108832-15-1
• Molecular Formula: C₁₅H₉Cl₂N
• Molecular Weight: 274.14
• Mol File: 108832-15-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 362.7 °C at 760 mmHg
• Flash Point: 204.6 °C
• Appearance: /
• Density: 1.331 g/cm³
• Vapor Pressure: 3.95E-05mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 2,4-DICHLORO-3-PHENYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-3-PHENYLQUINOLINE(108832-15-1)
• EPA Substance Registry System: 2,4-DICHLORO-3-PHENYLQUINOLINE(108832-15-1)

Safety Data

• Hazardous Substances Data: 108832-15-1(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-3-phenylquinoline is an organic chemical compound with the molecular formula C15H9Cl2N. It belongs to the class of quinoline compounds, which are aromatic heterocyclic organic compounds. This chemical is known for its pharmaceutical applications, particularly in the field of medicinal chemistry. It has been studied for its potential as an anti-cancer and anti-inflammatory agent. Additionally, it has shown promise as a potential inhibitor of protein kinases, which are enzymes that play a crucial role in cell signaling and regulation. Its chemical structure and properties make it a valuable compound for further research in drug development and medicinal chemistry.

InChI:InChI=1/C15H9Cl2N/c16-14-11-8-4-5-9-12(11)18-15(17)13(14)10-6-2-1-3-7-10/h1-9H

Upstream product

• 14933-29-0 4-hydroxy-3-phenyl-2(1H)-quinolone 
• 144603-33-8 3-chloro-1-methyl-3-phenylquinoline-2,4(1H,3H)-dione 
• 477950-26-8 1-benzyl-4-hydroxy-3-phenyl-1,2-dihydroquinolin-2-one 
• 519-66-4 4-hydroxy-1-methyl-3-phenylquinolin-2-one 
• 144603-32-7 3-chloro-3-phenylquinoline-2,4(1H,3H)-dione 
• 83-13-6 diethyl 2-phenylmalonate 
• 62-53-3 aniline 
• 20628-57-3 ethyl 2-(phenylcarbamoyl)-2-phenylacetate 
• 76281-01-1 3-phenyl-1H-quinoline-2,4-dione 
• 14933-29-0 3-phenyl-quinoline-2,4-diol 

Downstream Products

• 868860-38-2 2,4-Dimethoxy-3-phenyl-quinoline 
• 108832-11-7 4-Azido-2-chloro-3-phenylquinoline 
• 157027-42-4 5-Chloro-4-phenyl-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene 
• 160563-08-6 2-chloro-4-t-butylthio-3-phenylquinoline 
• 160563-17-7 2,4-di(2-propylthio)-3-phenylquinoline 
• 893616-39-2 3-phenylquinoline-2,4-dicarbonitrile 
• 89081-07-2 [2-(4-Methoxy-3-phenyl-quinolin-2-ylsulfanyl)-ethyl]-dimethyl-amine 
• 89080-84-2 4-methoxy-3-phenylquinolin-2-thione 
• 28563-01-1 4-methoxy-3-phenyl-2(1H)-quinolone 
• 157027-51-5 C₃₃H₂₄ClN₂P 
• 157027-53-7 4-chloro-3-phenyl-2-(triphenylphosphoranylideneamino)-quinoline 
• 72004-74-1 4-amino-3-phenylquinoline-2<1H>-one 

Relevant articles and documents

Reaction of some 2-quinolone derivatives with phosphoryl chloride: Synthesis of novel phosphoric acid esters of 4-hydroxy-2-quinolone

3-Chloroquinoline-2,4-diones do not react with phosphoryl chloride, however, 2,4-dichloroquinolines and/or 4-chloroquinolin-2-ones are formed in the presence of N,N-dimethylaniline. Along with these compounds, small quantities of novel dihydrogen phosphates of 4-hydroxyquinolin-2-ones were isolated. We outline a simple procedure that allows for the preparation of these compounds in moderate to good yields. All compounds were characterized by 1H and 13C NMR, IR, EI-MS, and ESI-MS spectroscopy, and in select cases by 31P NMR spectroscopy.

Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines

On the basis of the structure-activity relationship (SAR) of 4-chloro-6-nitroquipazine (Ki = 0.03 nM) and 3-fluoropropyl-6- nitroquipazine (Ki = 0.32 nM), 3-alkyl-4-halo-6-nitroquipazines were synthesized and tested for their potenti