1092661-31-8

Basic information

• Product Name: 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine
• Synonyms: 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine
• CAS NO: 1092661-31-8
• Molecular Weight: 727.898
• Mol File: 1092661-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine(1092661-31-8)
• EPA Substance Registry System: 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine(1092661-31-8)

Safety Data

• Hazardous Substances Data: 1092661-31-8(Hazardous Substances Data)

Upstream product

• 14565-47-0 N-succinimidyl laurate 
• 177980-10-8 2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 

Downstream Products

• 1092661-32-9 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine-3'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite) 

Relevant articles and documents

2′-Lipid-modified oligonucleotides via a 'Staudinger-Vilarrasa' reaction

We report a new access to 2′-amido-2′-deoxyuridine via a Staudinger-Vilarrasa coupling reaction for the preparation of lipid-modified oligonucleotides. One or two lipidic moieties were inserted within the oligonucleotidic sequence (LONs) leading to a repertoire of original antagomir-like molecules targeting micro RNA (miRNA or miR). Melting temperature (Tm) experiments revealed that the stability of the duplexes depends on the lipid position and the number of lipid moieties inserted within the oligonucleotide sequence. Single lipid conjugations of positions 11 and 19 of LONs targeting miR-122 do not destabilize the duplexes.