177980-10-8

Basic information

• Product Name: Uridine, 2'-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-
• Synonyms: 5'-O-dimethoxytrityl-2'-azido-2'-deoxyuridine;5'-O-(4,4'-dimethoxytrityl)-2'-azido-2'-deoxyuridine;2’-azido-2’-deoxyuridine;2'-azido-5'-O-dimethoxytrityl-2'-deoxyuridine;2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
• CAS NO: 177980-10-8
• Molecular Formula: C30H29N5O7
• Molecular Weight: 571.59
• Mol File: 177980-10-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Uridine, 2'-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 2'-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-(177980-10-8)
• EPA Substance Registry System: Uridine, 2'-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-(177980-10-8)

Safety Data

• Hazardous Substances Data: 177980-10-8(Hazardous Substances Data)

Usage

General Description

Uridine, 2'-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy- is a modified form of uridine, a nucleoside in RNA. This specific chemical compound has a 2'-azido-5'-O-[bis(4-methoxyphenyl)phenylmethyl] group attached to the 2'-deoxyribose moiety of uridine. This modification alters the structure and properties of the molecule, potentially impacting its biological activity and interactions. The compound may be used in research and pharmaceutical development for studying nucleic acid structures, modifying RNA function, or developing new drugs. Additionally, it could have potential applications in the development of nucleoside analogs for antiviral or anticancer therapies.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 26929-65-7 2'-azido-2'-deoxyuridine 
• 31501-46-9 (2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-2,3,3a,9a-tetrahydro-6H-furo[2,3’:4,5]oxazolo[3,2-a]pyrimidin-6-one 
• 58-96-8 uridine 
• 3736-77-4 2,2'-Anhydrouridine 
• 174221-86-4 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine 
• 173170-12-2 2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil 

Downstream Products

• 177980-09-5 3'-O-acetyl-2'-azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 
• 174221-87-5 2'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine 
• 213487-23-1 2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine 
• 807370-67-8 1-{(2R,3R,4S,5R)-3-Azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-trimethylsilanyloxy-tetrahydro-furan-2-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 807370-85-0 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamino-2'-deoxycytidine 
• 807370-92-9 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamino-2'-deoxycytidine 
• 1092661-31-8 5'-O-dimethoxytrityl-2'-[(dodecanoyl)amino]-2'-deoxyuridine 
• 1528642-08-1 2'-azido-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-(1,2,4-triazol-1-yl)uridine 
• 1528642-20-7 2'-azido-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N₄-(allyloxycarbonylaminoethyl)cytidine 
• 1528642-23-0 2'-amino-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N₄-(allyloxycarbonylaminoethyl)cytidine 
• 1528642-26-3 2'-(anthraquinone-2-ylcarboxamido)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N₄-(allyloxycarbonylaminoethyl)cytidine 
• 1350452-71-9 5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-(pyrene-1-yl)-carboxamidomethyl-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine 
• 1350452-76-4 3'-O-(N,N-diisopropylamino-2-cyanoethoxyphosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-(pyrene-1-yl)-carboxamidomethyl-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine 
• 1350452-68-4 5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-(pyrene-1-yl)-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine 

Relevant articles and documents

A direct comparison of azide and nitrile vibrational probes

The synthesis of 2′-azido-5-cyano-2′-deoxyuridine, N 3CNdU (1), from trityl-protected 2′-amino-2′-deoxyuridine was accomplished in four steps with a 12.5% overall yield. The IR absorption positions and profiles of the azide and nitrile group of

Chemical synthesis of site-specifically 2'-azido-modified RNA and potential applications for bioconjugation and RNA interference

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Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics

The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.