110-68-9

Basic information

• Product Name: N-METHYLBUTYLAMINE
• Synonyms: N-N-BUTYLMETHYLAMINE;N-Methyl-1-butylamine;N-Methyl-1-butaneamine;N-Methylbutylamine,98%;N-MethylbutylaMine, 98% 100ML;N-MethylbutylaMine, 98% 500ML;N-Methylbutylamine;N-Methylbutylamine for synthesis
• CAS NO: 110-68-9
• Molecular Formula: C₅H₁₃N
• Molecular Weight: 87.16
• EINECS: 203-791-2
• Mol File: 110-68-9.mol
• Article Data: 41

Chemical Properties

• Melting Point: -75 °C
• Boiling Point: 90.5-91.5 °C(lit.)
• Flash Point: 35 °F
• Appearance: /
• Density: 0.736 g/mL at 25 °C(lit.)
• Vapor Pressure: 53.7mmHg at 25°C
• Refractive Index: n20/D 1.3995(lit.)
• Storage Temp.: Flammables area
• PKA: pK1: 10.90(+1) (25°C)
• Explosive Limit: 1.3%(V)
• BRN: 1209231
• CAS DataBase Reference: N-METHYLBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLBUTYLAMINE(110-68-9)
• EPA Substance Registry System: N-METHYLBUTYLAMINE(110-68-9)

Safety Data

• Hazard Codes: F,C
• Statements: 11-20/21/22-34
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2945 3/PG 2
• WGK Germany: 3
• RTECS: EO5250000
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 110-68-9(Hazardous Substances Data)

Usage

Description

N-METHYLBUTYLAMINE, also known as a secondary aliphatic amine, is a water-white liquid with an ammonia-like odor. It has a density of 0.736 g/cm3 and a flash point of 35°F (Aldrich). Its vapors are heavier than air, and it is primarily used as an intermediate to make other chemicals. The chemical structure of N-METHYLBUTYLAMINE consists of methyl and n-butyl as the two alkyl groups.

Uses

Used in Chemical Synthesis:
N-METHYLBUTYLAMINE is used as an intermediate for the production of various chemicals. Its versatile chemical properties allow it to be a key component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
N-METHYLBUTYLAMINE is used as a building block for the development of pharmaceutical compounds. Its unique structure enables it to be incorporated into drug molecules, potentially enhancing their efficacy and targeting specific biological pathways.
Used in Agrochemical Industry:
N-METHYLBUTYLAMINE is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its role in these applications is to provide a stable and effective platform for the development of compounds that can protect crops and enhance agricultural productivity.
Used in Diverse Industrial Applications:
N-METHYLBUTYLAMINE is used as a versatile building block in various industrial applications, including the production of surfactants, lubricants, and additives. Its chemical properties make it suitable for a wide range of uses, contributing to the development of innovative products and technologies.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

N-METHYLBUTYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, dangerous fire risk.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, skin contact, and intraperitoneal routes. Mildly toxic by inhalation. A skin and severe eye irritant. Flammable liquid when exposed to heat, sparks, or flame. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.

Potential Exposure

Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs

Shipping

UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

Incompatibilities

May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.

InChI:InChI=1/C5H13N/c1-3-4-5-6-2/h6H,3-5H2,1-2H3/p+1

Upstream product

• 110-86-1 pyridine 
• 927-62-8 N,N-dimethylbutylamine 
• 94-36-0 dibenzoyl peroxide 
• 871-71-6 N-butylformamide 
• 6898-69-7 butylidene-methyl-amine 
• 31844-65-2 N-Butyl-N-methylbenzenemethanamine 
• 123-72-8 butyraldehyde 
• 74-89-5 methylamine 
• 109-65-9 1-bromo-butane 
• 542-69-8 1-iodo-butane 
• 593-51-1 methylamine hydrochloride 
• 123-73-9 crotonaldehyde 
• 103-67-3 benzyl-methyl-amine 
• 109-72-8 n-butyllithium 

Downstream Products

• 1515-72-6 N-butylphthalimide 
• 3405-45-6 N-methyldibutylamine 
• 120-94-5 1-Methylpyrrolidine 
• 35204-33-2 N-(2-aminophenyl)-2-(N-methyl-N-n-butylamino)acetamide 
• 512190-31-7 C₆H₅BClN(CH₃)(n-C₄H₉) 
• 52317-76-7 1-Butyl-3-(2,4-dimethyl-phenyl)-1-methyl-thiourea 
• 52317-80-3 3-(4-Bromo-2-methyl-phenyl)-1-butyl-1-methyl-thiourea 
• 57181-81-4 N-Butyl-2-chloro-N-methyl-3-[4-(1-phenyl-ethoxy)-phenyl]-propionamide 
• 16784-08-0 Rifamycin-B- 
• 52317-93-8 1-Butyl-3-(4-fluoro-2-methyl-phenyl)-1-methyl-thiourea 
• 64798-03-4 1-Butyl-3-[1-(4-fluoro-phenyl)-1-methyl-ethyl]-1-methyl-urea 
• 64797-90-6 3-[1-(3-Bromo-phenyl)-1-methyl-ethyl]-1-butyl-1-methyl-urea 
• 64796-86-7 1-Butyl-3-[1-(4-chloro-phenyl)-1-methyl-ethyl]-1-methyl-urea 
• 64796-37-8 1-Butyl-3-[1-(2-chloro-phenyl)-1-methyl-ethyl]-1-methyl-urea 

Relevant articles and documents

Electron Transfer on the Photodehalogenation of 2-(4-chlorophenyl)benzoxazole Assisted by Amines

The photochemical reactivity of 2-(4-chlorophenyl)benzoxazole in the presence of a series of amines has been investigated.A fluorescence quenching study provides evidence for the formation of an exciplex between the singlet excited state of the benzoxazole derivative and the amine in its ground state.This exciplex gives rise to a charge-transfer complex (CTC).The quenching fluorescence date can be fitted by a Weller-Marcus system, thus leading to large reorganization energies.The measurment of dehalogenation, which is drastically increased in the presence of amines, allowed us to estimate the reactivity of the CTC.In the case of tertiary amines, 1percent of the CTC formed via the singlet state leads to the dehalogenation.For secondary amines a hydrogen transfer between the amine and the excited triplet state of the chloro compound is also postulated.

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A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics

The kinetics of quinuclidine displacement of BH3 from a wide range of Lewis base borane adducts have been measured. Parameterization of these rates has enabled the development of a nucleofugality scale (NFB), shown to quantify and predict the leaving group ability of a range of other Lewis bases. Additivity observed across a number of series R′3-nRnX (X = P, N; R′ = aryl, alkyl) has allowed the formulation of related substituent parameters (nfPB, nfAB), providing a means of calculating NFB values for a range of Lewis bases that extends far beyond those experimentally derived. The utility of the nucleofugality parameter is explored by the correlation of the substituent parameter nfPB with the hydrolyses rates of a series of alkyl and aryl MIDA boronates under neutral conditions. This has allowed the identification of MIDA boronates with heteroatoms proximal to the reacting center, showing unusual kinetic lability or stability to hydrolysis.

Copper(II)-Catalyzed Selective Reductive Methylation of Amines with Formic Acid: An Option for Indirect Utilization of CO2

A copper-catalyzed protocol for reductive methylation of amines and imine with formic acid as a C1 source and phenylsilane as a reductant is reported for the first time, affording the corresponding methylamines in good to excellent yields under mild conditions. This protocol offers an alternative method for indirect utilization of CO2, as formic acid can be readily obtained from hydrogenation of CO2.

Selective N-methylation of aliphatic amines with CO2 and hydrosilanes using nickel-phosphine catalysts

A method using CO2 and PhSiH3 for the methylation of primary and secondary aliphatic amines catalyzed by Ni (0) complexes was developed, selectively producing the monomethylated products in moderate to good yields. For that purpose, two catalysts were used: [(dippe)Ni(μ-H)]2 and the commercially available Ni(COD)2/dcype, both of which were rather efficient in this process. With a slight experimental modification, the reaction allowed the production of monomethylated ureas in good yields by using low amounts of PhSiH3. On the basis of the experimental results, we propose a possible reaction mechanism for the formation of the new C-N bond.