927-62-8

Basic information

• Product Name: N,N-Dimethylaminobutane
• Synonyms: 1-Butanamine,N,N-dimethyl-;ar84996;Butylamine, N,N-dimethyl-;Butyldimethylamine;butyl-dimethyl-amine;n,n-dimethyl-1-butanamin;N,N-Dimethyl-1-butanamine;n,n-dimethyl-butylamin
• CAS NO: 927-62-8
• Molecular Formula: C₆H₁₅N
• Molecular Weight: 101.19
• EINECS: 213-156-1
• Mol File: 927-62-8.mol
• Article Data: 32

Chemical Properties

• Melting Point: -60 °C
• Boiling Point: 93.3 °C750 mm Hg(lit.)
• Flash Point: 25 °F
• Appearance: colourless liquid
• Density: 0.721 g/mL at 25 °C(lit.)
• Vapor Pressure: 44.6mmHg at 25°C
• Refractive Index: n20/D 1.398(lit.)
• PKA: 9.83±0.28(Predicted)
• Water Solubility: 3.4 g/100 mL (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents, strong acids. Highly flammable - note low flashpoint.
• CAS DataBase Reference: N,N-Dimethylaminobutane(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethylaminobutane(927-62-8)
• EPA Substance Registry System: N,N-Dimethylaminobutane(927-62-8)

Safety Data

• Hazard Codes: F,C
• Statements: 11-20/22-34
• Safety Statements: 26-36/37/39-45-16
• RIDADR: UN 2733 3/PG 2
• WGK Germany: 1
• RTECS: EJ4039250
• F: 9-34
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 927-62-8(Hazardous Substances Data)

Usage

Chemical Properties

colourless liquid

Uses

Different sources of media describe the Uses of 927-62-8 differently. You can refer to the following data:
1. Dimethylbutylamine is used as a chemical intermediate.
2. N,N-Dimethylbutylamine (cas# 927-62-8) is in preparation of high-density rigid flame-retardant polyimide foam material.
3. N,N-Dimethylbutylamine is suitable for use in the fabrication of polystyrene-based nano-LC monolithic columns for the separation of protein molecules. It may be used as ion-pairing reagent in a study involving comparison of performance of six ion-pairing reagents as mobile phase modifiers for oligonucleotide LC/MS.

Definition

ChEBI: A tertiary amine consisting of n-butane having a dimethylamino substituent at the 1-position.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 7122, 1984 DOI: 10.1021/ja00335a042

General Description

A clear liquid with an ammonia-like odor. Flash point 20°F. Boiling point 201°F. Density 0.72 g / cm3. Ingestion may irritate or burn the mouth, throat, esophagus and stomach. May cause nausea, vomiting and diarrhea. Inhalation of vapors may irritate the respiratory system and cause pulmonary edema. Contact with the skin may cause burns. Eye contact may cause corrosion to the eyes and contact with the vapor may temporarily blur vision. Vapors heavier than air and may travel considerable distance to a source of ignition and flash back.

Air & Water Reactions

Highly flammable. Partially soluble in water.

Reactivity Profile

N,N-DIMETHYL-N-BUTYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Moderately toxic by ingestion. Low toxic- ity by inhalation and skin contact. A moderate eye irritant.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C6H15N/c1-4-5-6-7(2)3/h4-6H2,1-3H3/p+1

Upstream product

• 50-00-0 formaldehyd 
• 3858-78-4 n-butylamine hydrochloride 
• 760-79-2 N,N-dimethylbutyramide 
• 63951-24-6 n-butyltrimethylammonium hydroxyde 
• 7722-19-2 trimethylbutylammonium iodide 
• 141-43-5 ethanolamine 
• 67-56-1 methanol 
• 110-68-9 N-n-butyl-N-methylamine 
• 109-65-9 1-bromo-butane 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 55831-89-5 4-(dimethylamino)-1-butene 
• 106-98-9 1-butylene 
• 124-40-3 dimethyl amine 
• 187737-37-7 propene 

Downstream Products

• 50-00-0 formaldehyd 
• 110-68-9 N-n-butyl-N-methylamine 
• 123-72-8 butyraldehyde 
• 124-40-3 dimethyl amine 
• 72617-58-4 tris(N,N-dimethylbutyl)benzylammonium chloride 
• 3405-45-6 N-methyldibutylamine 
• 1117-72-2 N-methyl-N-n-butylformamide 
• 761-65-9 N,N-dibutylformamide 
• 71-36-3 butan-1-ol 
• 25291-17-2 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene 
• 10285-91-3 N-butyl-N-methyl-4-methylbenzenesulfonamide 
• 106-98-9 1-butylene 
• 4359-97-1 2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone 

Relevant articles and documents

Palladium-Assisted Amination of Olefins. A Mechanistic Study

The mechanism of the palladium-assisted amination of olefins has been studied by low-temperature NMR and ultraviolat spectroscopy, conductivity measurements, and stoichiometry and exchange studies.The specific sequence of steps followed strongly depends on the temperature of amine.With dimethylamine, the sequence consists of cleavage of the chloride bridge by the amine to give a single olefin-palladium-amine complex (2).This undergoes amination of the olefin and concomitant cyclization to form the β-aminoalkylpalladium complex (3) directly and dimethylammonium hydrochloride.In contrast, with diethylamine, the initially formed olefin-palladium-amine complex undergoes amination to form a discrete zwitterionic complex (6).This reacts slowly with additional added amine to give the chelating β-aminoalkylpalladium complex (7).

Intermittent synthesis method N and N -dimethyl n-butylamine

The invention relates to N. The invention N-dimethyln-butylamine intermittent synthesis method. Some conversion rates of the main synthetic method of the prior art are relatively low, and some byproducts can be generated, the separation difficulty is increased, the method is economical, N - methylbutylamine is not generated, the separation difficulty is increased, and the production difficulty is large. The method is characterized in that n-butylamine and N-formaldehyde are used as raw materials, and the molar ratio of n-butylamine, n-butylamine and formaldehyde is prepared under the conditions N - and 37 - 40% through nickel catalytic hydrogenation. 60 - 90 °C. 2 - 4 mpa 2 - 1 . 2.6 1. To the invention, a new nickel catalyst is selected. The catalyst cost is reduced, the reaction is prepared by taking n-butylamine and formaldehyde as raw materials, the reaction is simple, the selectivity is good, and the yield is higher.

Ionic liquid/H2O-mediated synthesis of mesoporous organic polymers and their application in methylation of amines

Mesoporous Tr?ger's base-functionalized polymers (Meso-TBPs) were prepared using a sulfonic acid group functionalized ionic liquid/H2O system, with surface areas up to 431 m2 g-1 and pore sizes of 3-15 nm. Ir(ii) coordinated Meso-TBPs exhibited extraordinary catalytic performance in the N-methylation of amines using methanol.