110698-31-2

Basic information

• Product Name: (E)-3-(2-Pentyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide
• Synonyms: (E)-3-(2-Pentyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide
• CAS NO: 110698-31-2
• Molecular Weight: 419.483
• Mol File: 110698-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-Pentyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-Pentyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide(110698-31-2)
• EPA Substance Registry System: (E)-3-(2-Pentyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide(110698-31-2)

Safety Data

• Hazardous Substances Data: 110698-31-2(Hazardous Substances Data)

Upstream product

• 110683-66-4 o-amylbenzyl alcohol 
• 59059-43-7 2-n-pentylbenzaldehyde 
• 110683-65-3 ((E)-2-Pent-1-enyl)-benzoic acid methyl ester 
• 26311-41-1 methyl o-amylbenzoate 
• 4122-56-9 methyl o-formylbenzoate 

Relevant articles and documents

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.