110912-11-3

Basic information

• Product Name: 1-acetyl-2-benzoyl-3-indolinone
• Synonyms: 1-acetyl-2-benzoyl-3-indolinone
• CAS NO: 110912-11-3
• Molecular Weight: 279.295
• Mol File: 110912-11-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-acetyl-2-benzoyl-3-indolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-2-benzoyl-3-indolinone(110912-11-3)
• EPA Substance Registry System: 1-acetyl-2-benzoyl-3-indolinone(110912-11-3)

Safety Data

• Hazardous Substances Data: 110912-11-3(Hazardous Substances Data)

Upstream product

• 16800-68-3 1-acetyl-2,3-dihydro-1H-indol-3-one 
• 100-52-7 benzaldehyde 
• 95542-12-4 1-acetyl-2-benzylideneindolin-3-one 
• 98-88-4 benzoyl chloride 
• 110912-16-8 1-acetyl-3-hydroxybenzoylindole 
• 110912-13-5 1-acetyl-2-(α-acetoxybenzyl)-3-indolinone 

Downstream Products

• 22078-82-6 2-benzoyl-3-hydroxyindole 
• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 

Relevant articles and documents

INTRODUCTION OF ACYL SUBSTITUTENTS AT POSITION 2 OF THE INDOLINONE RING

The acylation of 1-acetyl-3-indolinone at position 2 of the heterocycle was realized by the action of acetic and propionic anhydride in the presence of sulfuric acid.It was shown that the reaction takes place with a high yield through an O-acylation and a Fries rearrangement stage.The Fries rearrangement was used to convert the 1-acetyl-3-hydroxybenzoylindole into 1-acetyl-2-benzoyl-3-indolinone.The same β-diketone and also 1-acetyl-2-(p-chlorobenzoyl)-3-indolinone were obtained by the action of a mixture of acetic anhydride and sulfuric acid on the respective 1-acetyl-2-arylidene- 3-indolinones. 1-Acetyl-3-formyl-3-chloroindole was obtained by the reaction of 1-acetyl-3-indolinone with the Vilsmeier complex obtained from DMFA and phosphorus oxychloride.It was deacylated to 2-formyl-3-chloroindole.