1119-46-6 Usage
Description
5-Chlorovaleric acid, an organochlorine compound, is a derivative of pentanoic acid with a 5-chloro substituent. It is a colorless or light-colored clear liquid and is known for its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
5-Chlorovaleric acid is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its ability to derivatize L-hydroxyproline has been utilized in the synthesis of haptens HP1 and HP2, which are essential in the production of antibodies against L-hydroxyproline.
Used in Chemical Synthesis:
5-Chlorovaleric acid serves as a key building block in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries. Its unique chemical properties make it a valuable component in the development of new molecules with potential applications in different fields.
Used in Research and Development:
In the field of research and development, 5-Chlorovaleric acid is used to study its chemical properties and potential interactions with other compounds. This knowledge can be applied to develop new drugs, materials, or processes that can benefit various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1119-46-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,1 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1119-46:
(6*1)+(5*1)+(4*1)+(3*9)+(2*4)+(1*6)=56
56 % 10 = 6
So 1119-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H9ClO2/c6-4-2-1-3-5(7)8/h1-4H2,(H,7,8)
1119-46-6Relevant articles and documents
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Nagao,M. et al.
, p. 3447 - 3449 (1966)
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Strojny et al.
, p. 1241 (1962)
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Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides
Li, Chenchen,Li, Ruoling,Zhang, Bing,Zhao, Pei,Zhao, Wanxiang
supporting information, p. 10913 - 10917 (2020/05/25)
A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.
A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents
Nakamura, Akira,Kanou, Hodaka,Tanaka, Junki,Imamiya, Akira,Maegawa, Tomohiro,Miki, Yasuyoshi
supporting information, p. 541 - 544 (2018/02/07)
A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.
