112006-75-4

Basic information

• Product Name: 3-Pyridinecarboxamide,2-(aminosulfonyl)-N,N-dimethyl-
• Synonyms: N,N-Dimethylnicotinamide-2-sulfonamide;2-(Aminosulfonyl)-N,N-dimethyl-3-pyridinecarboxamide
• CAS NO: 112006-75-4
• Molecular Formula: C₈H₁₁N₃O₃S
• Molecular Weight: 229.2562
• EINECS: 413-440-7
• Product Categories: Amines;Pyridines
• Mol File: 112006-75-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 198-209 °C (decomp)
• Boiling Point: 488.9 °C at 760 mmHg
• Flash Point: 249.5 °C
• Appearance: /
• Density: 1.373 g/cm³
• Vapor Pressure: 1.04E-09mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 8.81±0.60(Predicted)
• CAS DataBase Reference: 3-Pyridinecarboxamide,2-(aminosulfonyl)-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide,2-(aminosulfonyl)-N,N-dimethyl-(112006-75-4)
• EPA Substance Registry System: 3-Pyridinecarboxamide,2-(aminosulfonyl)-N,N-dimethyl-(112006-75-4)

Safety Data

• Hazard Codes: Xi
• Statements: 43-52/53
• Safety Statements: 24-37-61-24/25
• Hazardous Substances Data: 112006-75-4(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow powder

Uses

N,N-Dimethylnicotinamide-2-sulfonamide (cas# 112006-75-4) is a compound useful in organic synthesis.

InChI:InChI=1/C8H11N3O3S/c1-11(2)8(12)6-4-3-5-10-7(6)15(9,13)14/h3-5H,1-2H3,(H2,9,13,14)

Upstream product

• 111991-09-4 nicosulfuron 
• 112006-58-3 2-sulfonyl chloride-N,N-dimethylnicotinamide 
• 2942-59-8 2-chloronicotinic acid 
• 52943-21-2 2-chloropyridine-3-carboxylic acid N,N-dimethylamide 
• 121050-19-9 2-mercapto-N,N-dimethylnicotinamide 
• 124-40-3 dimethyl amine 
• 100-54-9 pyridine-3-carbonitrile 
• 14906-64-0 3-cyanopyridine N-oxide 
• 112006-57-2 N,N-dimethyl-2-(phenylmethylthio)-3-pyridinecarboxamide 
• 1336-21-6 ammonium hydroxide 
• 178613-27-9 ethyl 2-mercaptonicotinate 

Downstream Products

• 111991-09-4 nicosulfuron 
• 138417-40-0 2-sulfo-nicotinic acid imide 

Relevant articles and documents

Preparation method of 2-aminosulfonyl-N, N-dimethyl nicotinamide

The invention provides a preparation method of 2-aminosulfonyl-N, N-dimethyl nicotinamide. The preparation method comprises the following steps: synthesizing 2-chlorine-N, N-dimethyl nicotinamide by taking 2-cyano-5-dimethylamino-2, 4-pentadienyl dicarboxamide and hydrochloric acid gas as raw materials, and reacting at the temperature of between 0 and 100 DEG C to synthesize the 2-chloro-N, N-dimethyl nicotinamide. Furthermore, the preparation method provided by the invention also comprises the step of sequentially synthesizing the 2-sulfydryl-N, N-dimethyl nicotinamide, the 2-chlorosulfonyl-N, N-dimethyl nicotinamide and the 2-aminosulfonyl-N, N-dimethyl nicotinamide by taking the 2-chloro-N, N-dimethyl nicotinamide as a raw material. According to the preparation method of the 2-aminosulfonyl-N, N-dimethyl nicotinamide, provided by the invention, the novel preparation method is provided by taking the 2-cyano-5-dimethylamino-2, 4-pentadiene dicarboxamide as an initial raw material, and the preparation method is relatively short in synthetic route, relatively high in yield and relatively low in cost.

Preparation method of nicosulfamide

The invention relates to the technical field of pesticide synthesis, in particular to a preparation method of nicosulfamide. The preparation method of the smoke sulfonamide comprises the following steps: taking 3-cyanopyridine as a raw material, and carrying out oxidation reaction to obtain 3-cyanopyridine nitric oxide; carrying out sulfonation reaction and ammoniation reaction on the 3-cyanopyridine nitrogen oxide to obtain 2-sulfonamido-3-cyanopyridine; carrying out alkaline hydrolysis on the 2-sulfamido-3-cyanopyridine to obtain 2-sulfamido nicotinic acid; and carrying out amidation reaction on the nicotinic acid 2-sulfonamide to obtain the nicotinamide. The preparation method of the nicosulfamide is simple to operate and low in raw material cost, by-products generated in the preparation process can be recycled, the cost is saved, and the prepared nicosulfamide is high in yield and purity.

Synthesis method of 2-aminosulfonyl-N, N-dimethyl nicotinamide

The invention belongs to the field of pesticides, relates to a synthesis technology of a nicosulfuron intermediate, in particular to a synthesis method of 2-aminosulfonyl-N, N-dimethyl nicotinamide. According to the method, 2-chloro-N, N-dimethyl nicotinamide and sodium thiosulfate are used as raw materials, the method comprises the processes of sulfhydrylation, sulfonation, ammoniation reaction and the like, the reaction process is few in by-product, high in yield and low in raw material cost, hydrogen sulfide is removed from the source of the reaction, real clean production is achieved, andthe product content and yield are increased.