112101-74-3 Usage
General Description
Acetamide,N-[(1R)-2-[3-(aminosulfonyl)-4-methoxyphenyl]-1-methylethyl]- is a chemical compound with the molecular formula C15H24N2O5S. It is a derivative of acetamide and contains a complex structure with a sulfonyl and methoxy group attached to a phenyl ring. This chemical is a chiral compound with a (1R) configuration and a propylamine side chain. It is used in pharmaceutical research and development, particularly in the study of potential drug candidates with anti-inflammatory and analgesic properties. The compound's unique structure and functional groups make it a valuable tool for therapeutic drug discovery and design.
Check Digit Verification of cas no
The CAS Registry Mumber 112101-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,0 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112101-74:
(8*1)+(7*1)+(6*2)+(5*1)+(4*0)+(3*1)+(2*7)+(1*4)=53
53 % 10 = 3
So 112101-74-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O4S/c1-8(14-9(2)15)6-10-4-5-11(18-3)12(7-10)19(13,16)17/h4-5,7-8H,6H2,1-3H3,(H,14,15)(H2,13,16,17)/t8-/m1/s1
112101-74-3Relevant articles and documents
Practical syntheses of N-acetyl (E)-β-arylenamides
Cai, Zhihua,Liu, Guodu,Jiao, Guangjun,Senanayake, Chris H.,Tang, Wenjun
, p. 3355 - 3360 (2014/01/06)
A facile and practical method for the preparation of (E)-β- arylenamides [(E)-N-(1-arylprop-1-en-2-yl]acetamides] has been developed by reductive acetylation of the corresponding oximes with iron(II) acetate as the reducing reagent. Employment of hexamethylphosphoramide as the solvent was found to be critical for the high E/Z selectivity. The methodology has been applied in efficient syntheses of a key chiral intermediate of tamsulosin by asymmetric hydrogenation. Georg Thieme Verlag Stuttgart . New York.
Process for preparation of tamsulosin and its derivatives
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Page/Page column 2; 5; 9-10; 14, (2008/06/13)
The present invention discloses a new process for the synthesis of tamsulosin derivatives of formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochlorides and other pharmaceutically acceptable salts, comprising reacting the hydrochloride of sulphonamide 2 (where R represents C 1 -C 4 alkyl) with the ether compound 21 (where R' represents C 1 -C 4 alkyl and R" represents MeC 6 H 4 SO 2 or MeSO 2 ).
