112372-07-3

Basic information

• Product Name: Furo[3,2-c]pyridine-2-carboxaldehyde (9CI)
• Synonyms: Furo[3,2-c]pyridine-2-carboxaldehyde (9CI)
• CAS NO: 112372-07-3
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.1308
• Product Categories: ALDEHYDE;PYRIDINE
• Mol File: 112372-07-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 129.5-130 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 286.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.322±0.06 g/cm3(Predicted)
• PKA: 3.39±0.40(Predicted)
• CAS DataBase Reference: Furo[3,2-c]pyridine-2-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,2-c]pyridine-2-carboxaldehyde (9CI)(112372-07-3)
• EPA Substance Registry System: Furo[3,2-c]pyridine-2-carboxaldehyde (9CI)(112372-07-3)

Safety Data

• Hazardous Substances Data: 112372-07-3(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 271-92-1 furo[3,2-c]pyridine 
• 478148-56-0 2-(diethoxymethyl)furo[3,2-c]pyridine 

Downstream Products

• 112372-13-1 2-cyanofuro<3,2-c>pyridine 
• 143707-98-6 5-Ethyl-3-[(furo[3,2-c]pyridin-2-ylmethyl)-amino]-6-methyl-1H-pyridin-2-one 

Relevant articles and documents

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

Furopyridines. VII. Preparation and Hydrolysis of 2-Cyano and 3-Cyano Derivatives of Furo-, Furo-, and Furopyridine

This paper describes the preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo-, furo-, and furopyridine.Treatment of furopyridines 1a, 1b and 1c with n-butyllithium in hexane-tetrahydrofuran at -70 deg C and subsequent addition of N,N-dimethylformamide yielded 2-formyl derivatives 2a, 2b and 2c.Dehydration of the oximes 4a, 4b and 4c of 2a, 2b and 2c gave 2-cyano compounds 5a, 5b and 5c, which were hydrolyzed to give 2-carboxylic acids, 6a, 6b and 6c, respectively.Reaction of 3-bromo compounds 7a, 7b and 7c with copper(I) cyanide in N,N-dimethylformamide afforded 3-cyano derivatives 8a, 8b and 8c.Alkaline hydrolysis of 8a, 8b and 8c gave compounds formed by fission of the 1-2 bond of furopyridines 9a, 9b and 9c, while acidic hydrolysis gave the corresponding carboxamides, 10a, 10b and 10c.