1126093-36-4

Basic information

• Product Name: (E)-2-chloro-5-cinnamylpyridine
• Synonyms: (E)-2-chloro-5-cinnamylpyridine
• CAS NO: 1126093-36-4
• Molecular Weight: 229.709
• Mol File: 1126093-36-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-chloro-5-cinnamylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-chloro-5-cinnamylpyridine(1126093-36-4)
• EPA Substance Registry System: (E)-2-chloro-5-cinnamylpyridine(1126093-36-4)

Safety Data

• Hazardous Substances Data: 1126093-36-4(Hazardous Substances Data)

Upstream product

• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 201852-49-5 potassium (E)-trifluoro(styryl)borate 

Relevant articles and documents

Palladium-catalyzed cross-coupling reactions of potassium alkenyltrifluoroborates with organic halides in aqueous media

Potassium vinyl and alkenyltrifluoroborates are cross-coupled with aryl and heteroaryl bromides using 1 mol % Pd loading of 4-hydroxyacetophenone oxime derived palladacycle or Pd(OAc)2 as precatalysts, K 2CO3 as base, and TBAB as additive and water reflux under conventional or microwave heating to afford styrenes, stilbenoids, and alkenylbenzenes. These borates can be cross-coupled diastereoselectively with allyl and benzyl chlorides using KOH as base in acetone-water (3:2) at 50°C and 0.1 mol % Pd loading, giving the corresponding 1,4-dienes and allylarenes, respectively. These simple phosphine-free reaction conditions allow the palladium recycling from the aqueous phase during up to five runs by extractive separation of the products, which contain 58-105 ppm of Pd.