112697-61-7

Basic information

• Product Name: 1,8-Naphthyridine-3-carboxamide,2-methyl-N-phenyl-(9CI)
• Synonyms: 1,8-Naphthyridine-3-carboxamide,2-methyl-N-phenyl-(9CI)
• CAS NO: 112697-61-7
• Molecular Formula: C₁₆H₁₃N₃O
• Molecular Weight: 263.29392
• Product Categories: NAPHTHYRIDINE
• Mol File: 112697-61-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 215 °C
• Boiling Point: 377.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.283±0.06 g/cm3(Predicted)
• PKA: 11.74±0.70(Predicted)
• CAS DataBase Reference: 1,8-Naphthyridine-3-carboxamide,2-methyl-N-phenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridine-3-carboxamide,2-methyl-N-phenyl-(9CI)(112697-61-7)
• EPA Substance Registry System: 1,8-Naphthyridine-3-carboxamide,2-methyl-N-phenyl-(9CI)(112697-61-7)

Safety Data

• Hazardous Substances Data: 112697-61-7(Hazardous Substances Data)

Usage

Chemical Class

Naphthyridine carboxamide

Biological Activity

Diverse range of activities, not extensively studied

Potential Pharmaceutical Applications

Medicinal chemistry

Structural Features

Methyl and phenyl groups on the nitrogen atom of the carboxamide moiety

Importance

Interesting target for further research and development due to potential influence on biological properties.

Upstream product

• 5174-88-9 2-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester 
• 62-53-3 aniline 
• 7521-41-7 2-Aminonicotinaldehyde 
• 102-01-2 N-phenylacetoacetamide 

Downstream Products

• 118965-57-4 2-Methyl-3-(1-phenyl-1H-tetrazol-5-yl)-[1,8]naphthyridine 

Relevant articles and documents

Indium(Iii) Chloride as an efficient catalyst for friedlander synthesis 1,8-Naphthyridines under solventfree conditions

InCl3 catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3 in high yields. The method is simple an

Cecl3.7H2O catalyzed Friedlander synthesis of 1,8-naphthyridines under solvent-free grinding conditions

CeCl3.7H2O catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with varius carbonyl compounds containing α-methylene group 2 in solvent-free grinding conditions to afford the corresponding 1,8-naphthyridines 3. The rea

An efficient Friedlander condensation using Zr(OH)2CO 3.ZrO2 as catalyst in the solid state

A simple and efficient Friedlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α- methylene group 2 under solid state conditions to prepare 1,8- naphthyridines 3 in very good yields using Zr(OH)2CO3