113030-24-3

Basic information

• Product Name: 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole
• Synonyms: 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole;2-AMINO-4,5-DIHYDROBENZO[D]THIAZOL-6(7H)-ONE;2-Amino-4,7-dihydro-6(5H)-benzothiazolone
• CAS NO: 113030-24-3
• Molecular Formula: C7H8N2OS
• Molecular Weight: 168.21622
• EINECS: -0
• Product Categories: Pharmaceutical intermediate;Amines, Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 113030-24-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 396.165°C at 760 mmHg
• Flash Point: 193.394°C
• Appearance: /
• Density: 1.429g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.65±0.20(Predicted)
• CAS DataBase Reference: 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole(113030-24-3)
• EPA Substance Registry System: 2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole(113030-24-3)

Safety Data

• Hazardous Substances Data: 113030-24-3(Hazardous Substances Data)

Usage

Uses

2-Amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole, is an intermediate in the synthesis of pharmaceutical and biologically active compounds including therapeutic agents. It is an intermediate for the synthesis of Pramipexole (P700755).

InChI:InChI=1/C7H8N2OS/c8-7-9-5-2-1-4(10)3-6(5)11-7/h1-3H2,(H2,8,9)

Upstream product

• 159015-33-5 2-amino-6-(ethylenedioxy)-4,5,6,7-tetrahydrobenzothiazole 
• 144810-01-5 1,4-cyclohexanedione-1-ethylene acetal 4-trimethylsilyl enol ether 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 404892-16-6 2-amino-6,6-dimethoxy-4,5,6,7-tetrahydrobenzothiazole Hydrobromide 
• 637-88-7 1,4-Cyclohexanedione 

Downstream Products

• 104617-86-9 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole 
• 106006-83-1 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole 
• 104632-25-9 pramipexole dihydrochloride 
• 106092-09-5 (S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine 
• 943319-02-6 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole p-toluenesulfonic acid 

Relevant articles and documents

Discovery of pyrazolopyrimidine derivatives as novel inhibitors of ataxia telangiectasia and rad3 related protein (ATR)

The ATR pathway is a critical mediator of the replication stress response in cells. In aberrantly proliferating cancer cells, this pathway can help maintain sufficient genomic integrity for cancer cell progression. Herein we describe the discovery of 19,

Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles

A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.