106092-09-5Relevant articles and documents
Preparation method of high-purity pramipexole
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Paragraph 0059-0061; 0068-0070, (2021/04/07)
The invention relates to the technical field of pharmacy, and provides a preparation method of high-purity pramipexole. According to the invention, raceme 2, 6-diamino 4, 5, 6, 7-tetrahydrobenzothiazole is used as an initial raw material, and pramipexole is obtained through a three-step chemical reaction, so the introduction of uncontrollable factors of drug quality is reduced, and the requirements of drug application are better met; the market price of the initial raw materials is low, so that the preparation cost of pramipexole can be greatly reduced; the solvent used in the method is green, environmentally friendly, cheap, easy to obtain and suitable for industrial production, the HPLC purity of the obtained pramipexole can reach 99.86%, and the isomer purity can reach 99.89%.
Alkali separation method of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole * L-tartrate
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Paragraph 0023-0042, (2020/01/25)
The invention relates to an alkali precipitation method of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole * L-tartrate, water is used as a solvent, and a mixed aqueous solution of sodium hydroxide and potassium hydroxide is dropped into an aqueous solution of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole * L-tartrate to precipitate (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole. The method hasthe advantages that (1) the blazing slag residue of the obtained product can be reduced, and the quality level of the product is improved; (2) the amount of the reaction solvent water is reduced, thereby reducing the discharge amount of waste water and being beneficial to environmental protection; (3) Because the (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole is soluble in water, the loss of theproduct is reduced and the yield of the product is also improved after the amount of water is reduced.
A preparation method of pramipexole hydrochloride (by machine translation)
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Paragraph 0057; 0059-0062, (2017/12/27)
The invention discloses a method for preparation of pramipexole hydrochloride, comprises the following steps: 1) in the organic solvent, in order to 2, 6 - diamino - 4, 5, 6, 7 - tetrahydrobenzo and thiazole as the raw material, to join the resolving agent, heating to reflux, cooling, filtering, basified, make the (-) - (6 s) - 2, 6 - diamino 4, 5, 6, 7 - tetrahydrobenzo and thiazole; 2) in ethanol solution, the (-) - (6 s) - 2, 6 - diamino 4, 5, 6, 7 - tetrahydrobenzo and thiazole, and c anhydride reaction, by heating to reflux, to obtain (-) - (6 s) - 2 - amino - 6 - propionyl amino - 4, 5, 6, 7 - tetrahydrobenzo and thiazole; 3) (-) - (6 s) - 2 - amino - 6 - propionyl amino - 4, 5, 6, 7 - tetrahydrobenzo and thiazole in toluene solution in red aluminum reduction reaction, by heating to reflux, stirring, after devitrifying, make the use of pramipexole; the pramipexole into the isopropyl alcohol solution, by stirring, after devitrifying, react with hydrochloric acid, by decompression, drying, hydrochloride pramipexole. The preparation method is reaction low requirements on the equipment, the pramipexole prepared hydrochloric acid content is high, high purity, high solubility, the output is high, there is little impurity. (by machine translation)