1140-38-1

Basic information

• Product Name: 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1H-Pyrazole-4-carboxylicacid, 5-chloro-3-Methyl-1-phenyl-;5-chloro-3-methyl-1-phenyl-4-pyrazolecarboxylic acid;5-chloro-3-methyl-1-phenyl-pyrazole-4-carboxylic acid;5-chloro-3-methyl-1-phenylpyrazole-4-carboxylic acid
• CAS NO: 1140-38-1
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.66
• Mol File: 1140-38-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 406.3 °C at 760 mmHg
• Flash Point: 199.5 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 2.49E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(1140-38-1)
• EPA Substance Registry System: 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(1140-38-1)

Safety Data

• Hazardous Substances Data: 1140-38-1(Hazardous Substances Data)

Usage

General Description

5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid is a chemical compound with a molecular formula of C13H10ClN3O2. It falls under the category of pyrazoles, which are aromatic organic compounds characterized by a five-membered ring with three carbon atoms and two nitrogen atoms. This specific chemical features additional functional groups including a phenyl group, a chloro group, a methyl group, and a carboxylic acid group, contributing to its unique physical and chemical properties. Its exact properties such as boiling point, melting point, and density can be determined through further analysis. As with other chemicals, its handling and storage should follow proper safety protocols to avoid potential hazards.

InChI:InChI=1/C11H9ClN2O2/c1-7-9(11(15)16)10(12)14(13-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,15,16)/p-1

Upstream product

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Downstream Products

• 188047-59-8 C₁₂H₈ClN₃OS 
• 1392131-63-3 1-(4-bromo-2-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-64-4 1-(2-fluorobenzyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-65-5 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-66-6 1-(2-fluoro-3-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-67-7 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1426433-94-4 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid azide 
• 1426434-04-9 N¹-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-N³-(2-chlorophenyl)urea 
• 1426434-05-0 N¹-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-N³-(2-methylphenyl)urea 
• 1426434-06-1 N¹-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-N³-(4-hydroxyphenyl)urea 
• 1426433-95-5 N¹,N⁴-bis-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)piperazine-1,4-dicarboxamide 
• 1426433-96-6 1,4-di(3-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)ureido)benzene 

Relevant articles and documents

Design, synthesis, antibacterial evaluation and molecular docking studies of novel pyrazole/1,2,4-oxadiazole conjugate ester derivatives

The development of new antimicrobial drugs is most needed due to rapid growth in global antimicrobial resistance. Thus, in this context, a series of novel pyrazole/1,2,4-oxadiazole conjugate ester derivatives (7a–j) was synthesized. All the derivatives we

Electrosynthesis of 5-chloro- and 5-azido-4-pyrazole carboxylic acid at the nickel hydroxide electrode

Pyrazole derivatives are valuable intermediates for drugs and agrochemicals. The literature seems to be almost devoid of suitable methods, from environmental point of view for the preparation of simple pyrazole carboxylic acid derivatives which could be prepared from aldehydes with oxidizing agents such as NaCIO4. These reagents are partially toxic and large scale conversions create waste disposal problems. A clean oxidation technique would be the indirect electrochemical oxidation at the nickel hydroxide anode. Until recently there have been few examples of oxidation of heterocyclic aldehydes to the corresponding acids. We represent here an electrochemical method for oxidizing 5-chloro-4-pyrazole carbaldehyde (1) and 5-azido-4-pyrazole carbaldehyde (2) to their corresponding acids (3 and 4) at a nickel hydroxide anode in good yields (80-85%) (scheme 1).

Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides

The pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In th

Discovery of novel triazole-containing pyrazole ester derivatives as potential antibacterial agents

To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the most potent antibacterial activity with Minimum inhibitory concentration (MIC) alues of 4 μg/mL, 2 μg/mL, 4 μg/mL, and 0.5 μg/mL against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella gallinarum, respectively. The in vivo enzyme inhibition assay 4d displayed the most potent topoisomerase II (IC50 = 13.5 μg/mL) and topoisomerase IV (IC50 = 24.2 μg/mL) inhibitory activity. Molecular docking was performed to position compound 4d into the topoisomerase II active site to determine the probable binding conformation. In summary, compound 4d may serve as potential topoisomerase II inhibitor.