83-10-3

Basic information

• Product Name: ANTIPYRINECARBOXYLIC ACID
• Synonyms: ANTIPYRINECARBOXYLIC ACID;RARECHEM AL BE 0663;1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid;ANTIPYRIC ACID;1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolecarboxylic acid;1,5-dimethyl-3-oxo-2-phenyl-pyrazole-4-carboxylic acid;1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-
• CAS NO: 83-10-3
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.24
• EINECS: 201-215-5
• Mol File: 83-10-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 214 °C
• Boiling Point: 363°Cat760mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.342g/cm³
• Vapor Pressure: 6.65E-06mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• PKA: 6.47±0.20(Predicted)
• CAS DataBase Reference: ANTIPYRINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ANTIPYRINECARBOXYLIC ACID(83-10-3)
• EPA Substance Registry System: ANTIPYRINECARBOXYLIC ACID(83-10-3)

Safety Data

• Hazardous Substances Data: 83-10-3(Hazardous Substances Data)

Usage

General Description

Antipyrinecarboxylic acid, also known as 4-hydroxyantipyrine or 4-hydroxyphenazone, is a chemical compound that is derived from antipyrine. It is a metabolite of antipyrine, a medication used to treat fever and pain, and it has similar analgesic and antipyretic properties. Antipyrinecarboxylic acid is formed in the liver when antipyrine is metabolized, and it is excreted in the urine. Research has shown that it has potential anti-inflammatory and antioxidant properties, and it may be useful for treating conditions such as rheumatoid arthritis and oxidative stress-related disorders. However, further studies are needed to fully understand its therapeutic potential and safety profile.

InChI:InChI=1/C12H12N2O3/c1-8-10(12(16)17)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,1-2H3,(H,16,17)

Upstream product

• 75-44-5 phosgene 
• 60-80-0 antipyrine 
• 71-43-2 benzene 
• 10013-09-9 1-phenyl-2,3-dimethyl-4-hydroxymethyl-pyrazoline-5-on 
• 6538-52-9 (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-glyoxylic acid 
• 144481-38-9 1,5-dimethyl-2-phenyl-4-trichloroacetyl-1,2-dihydro-pyrazol-3-one 
• 107056-79-1 (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-glyoxylic acid ethyl ester 
• 108875-23-6 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid dimethylamide 
• 40570-67-0 4-acetyl-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one 
• 132624-53-4 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-thiocarbonyl)-morpholine 
• 950-81-2 4-formyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 
• 66379-85-9 1,5-dimethyl-2-phenyl-4-(2,2,2-trichloro-1-hydroxy-ethyl)-1,2-dihydro-pyrazol-3-one 

Downstream Products

• 873413-12-8 bis-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-ketone 
• 1140-38-1 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carboxylic acid 
• 61226-21-9 Antipyrinsaeurechlorid 
• 1221713-69-4 N-(4-(5-bromopyrrolo[1,2-b]pyridazin-4-yloxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1221713-71-8 N-(3-fluoro-4-(5-phenylpyrrolo[1,2-b]pyridazin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1221713-88-7 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid [3-fluoro-4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]-amide 
• 1552280-90-6 3-chloro-4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide 
• 1552281-00-1 N-(3-fluoro-4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1552280-92-8 4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2,3-difluorophenoxy)picolinamide 
• 60-80-0 antipyrine 
• 5426-65-3 4-bromoantipyrine 
• 1558011-45-2 N-[3-fluoro-4-({6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl}oxy)phenyl]-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1558011-44-1 N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1552280-98-4 N-(5-hydroxypyridin-2-yl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 

Relevant articles and documents

Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives

Deregulation of c-Met receptor tyrosine kinase activity leads to tumorigenesis and metastasis in animal models. More importantly, the identification of activating mutations in c-Met, as well as MET gene amplification in human cancers, points to c-Met as a

AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET

The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.