114058-74-1

Basic information

• Product Name: 2-CHLORO-4-METHYL-7-AMINOQUINOLINE
• Synonyms: 2-CHLORO-4-METHYL-7-AMINOQUINOLINE
• CAS NO: 114058-74-1
• Molecular Formula: C₁₀H₉ClN₂
• Molecular Weight: 192.64
• Mol File: 114058-74-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 65-66 °C
• Boiling Point: 372.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.307±0.06 g/cm3(Predicted)
• PKA: 2?+-.0.50(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-METHYL-7-AMINOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHYL-7-AMINOQUINOLINE(114058-74-1)
• EPA Substance Registry System: 2-CHLORO-4-METHYL-7-AMINOQUINOLINE(114058-74-1)

Safety Data

• Hazardous Substances Data: 114058-74-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methyl-7-aminoquinoline is a chemical compound with the molecular formula C10H10ClN3. It is a derivative of quinoline and is commonly used as an anti-malarial drug. 2-CHLORO-4-METHYL-7-AMINOQUINOLINE is known for its potent antimalarial activity and has been used in the treatment of malaria caused by chloroquine-resistant strains of Plasmodium falciparum. 2-Chloro-4-methyl-7-aminoquinoline works by inhibiting the growth and replication of the malaria parasite within the red blood cells. Its chemical structure and mode of action make it a valuable tool in the fight against malaria, a disease that continues to be a major global health concern.

Upstream product

• 19840-99-4 7-amino-4-methylcarbostyril 
• 7647-01-0 hydrogenchloride 
• 10025-87-3 trichlorophosphate 
• 141-97-9 ethyl acetoacetate 
• 19840-99-4 carbostyril 124 
• 108-45-2 m-phenylenediamine 

Downstream Products

• 114058-79-6 7-amino-4-methylquinoline 
• 52507-64-9 7-Acetamido-2-chlorlepidin 
• 634-47-9 2-chloro-4-methylquinoline 

Relevant articles and documents

A new quinoline sensitizer-centered lanthanide chelate and its use for protein labling on Ni-NTA beads for TR LRET assays

A quinoline sensitizer-centered lanthanide chelate system of novel design for TR-LRET was prepared; it exhibited high labelling efficiency with a his-tagged protein (ERα-LBD) on the Ni-NTA beads, using a mixed metal chelate protocol, and it functioned wel

Sulfonamide-containing heterocyclic compounds

The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, A is hydrogen atom, a halogen atom, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, or cyano group; B is an optionally substituted aryl group or monocyclic heteroaryl group, or: (wherein, the ring Q is an aromatic ring which may have nitrogen atom; and the ring M is a ring sharing a double bond with the ring Q, which ring may have a heteroatom; and the rings Q and M may share nitrogen atom); K is a single bond; T, W, X and Y are the same as or different from each other and each is ═C(D)— (wherein, D is hydrogen or a halogen atom) or nitrogen atom; U and V are the same as or different from each other and each is ═C(D)—, nitrogen atom, —CH2—, oxygen atom or —CO—; Z is a single bond or —CO—NH—; and R1 is hydrogen atom, etc.

7-Aminoquinolines. A novel class of agents active against herpesviruses

A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 μg/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two- to fivefold higher than those required for antiviral activity. Nonetheless, six compounds (10, 28, 29, 32, 34, and 36) were identified in which the separation was greater than fivefold. All compounds examined were more potent inhibitors of viral DNA synthesis than the cellular DNA synthesis.