1150098-34-2

Basic information

• Product Name: 7-(2-Fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide
• Synonyms: 7-(2-Fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide
• CAS NO: 1150098-34-2
• Molecular Weight: 487.269
• Mol File: 1150098-34-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-(2-Fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2-Fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide(1150098-34-2)
• EPA Substance Registry System: 7-(2-Fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide(1150098-34-2)

Safety Data

• Hazardous Substances Data: 1150098-34-2(Hazardous Substances Data)

Upstream product

• 116993-42-1 7-Hydroxy-8-(ethoxycarbonyl)-6-methyl-2,3-dihydro-1H-indolizin-5-one 
• 16631-18-8 diethyl 2-methylacetonedicarboxylate 
• 1150098-37-5 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 
• 1150098-36-4 7-chloro-6-methyl-5-oxo-1,2,3, 5-tetrahydro-indolizine-8-carboxylic acid 
• 1150098-35-3 7-chloro-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 

Relevant articles and documents

Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy

The structure-based design, synthesis, and biological evaluation of two novel series of potent and selective MEK kinase inhibitors are described herein. The elaboration of a lead pyrrole derivative to a bicyclic dihydroindolone core provided compounds wit

Heterocyclic Compounds as MEK Inhibitors

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.