1150098-37-5Relevant articles and documents
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy
Adams, Mark E.,Wallace, Michael B.,Kanouni, Toufike,Scorah, Nicholas,O'Connell, Shawn M.,Miyake, Hiroshi,Shi, Lihong,Halkowycz, Petro,Zhang, Lilly,Dong, Qing
, p. 2411 - 2414 (2012/05/05)
The structure-based design, synthesis, and biological evaluation of two novel series of potent and selective MEK kinase inhibitors are described herein. The elaboration of a lead pyrrole derivative to a bicyclic dihydroindolone core provided compounds wit
Heterocyclic Compounds as MEK Inhibitors
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Page/Page column 80-81, (2009/12/02)
The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.