115348-15-7

Basic information

• Product Name: N,N-diethyl-2-(4-methoxyphenyl)acetamide
• Synonyms: benzeneacetamide, N,N-diethyl-4-methoxy-; N,N-Diethyl-2-(4-methoxy-phenyl)-acetamide
• CAS NO: 115348-15-7
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.2955
• Mol File: 115348-15-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 349.8°C at 760 mmHg
• Flash Point: 165.3°C
• Density: 1.021g/cm³
• Vapor Pressure: 4.6E-05mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: N,N-diethyl-2-(4-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-(4-methoxyphenyl)acetamide(115348-15-7)
• EPA Substance Registry System: N,N-diethyl-2-(4-methoxyphenyl)acetamide(115348-15-7)

Safety Data

• Hazardous Substances Data: 115348-15-7(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 660-68-4 diethyl amine hydrochloride 
• 162147-95-7 2-chloro-1-(4-methoxyphenyl)-2-(phenylsulfinyl)-1-ethanone 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 50653-15-1 N,N-Diaethylamino-carbonylmethyl-zinkbromid 
• 685-91-6 diethylacetamide 
• 104-01-8 4-Methoxyphenylacetic acid 
• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 1497283-38-1 C₁₃H₁₉NO₂ 
• 58784-42-2 4-methoxyphenylketene 
• 623-12-1 4-chloromethoxybenzene 
• 6832-17-3 2-diazo-1-(4-methoxyphenyl)ethanone 

Downstream Products

• 35144-39-9 1-(4-methoxyphenyl)-2-methylpropan-2-ol 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 1610734-24-1 2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-(4-methoxyphenyl)acetamide 
• 1449216-36-7 N,N-diethyl-2,2-bis(4-methoxyphenyl)acetamide 
• 137958-85-1 N,N-diethyl-2-(4-methoxyphenyl)acrylamide 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 1422748-02-4 2-(2,6-dibenzoyl-4-methoxyphenyl)-N,N-diethylacetamide 

Relevant articles and documents

Preparation method of aryl acetamide compound

The invention discloses a preparation method of an aryl acetamide compound. The method comprises the following steps: adding a palladium catalyst, a ligand, benzyl formate, tertiary amine and trifluoroacetic anhydride into an organic solvent, performing reacting at 130 DEG C for 24 hours, and after the reaction is completed, carrying out after-treatment to obtain the aryl acetamide compound. The preparation method is easy to operate, the after-treatment is simple and convenient, reaction initial raw materials are cheap and easily available, benzyl formate is taken as both a carbon monoxide source and a reactant, tertiary amine is taken as an amine source, substrate designability is high, substrate functional group tolerance range is wide, and reaction efficiency is high. What is noteworthyis that C-N bonds of the tertiary amine are broken in the reaction, no extra oxidizing agent is needed, various aryl acetamide compounds can be synthesized according to actual needs, and practicability is high.

P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions

A variant of P450 from Bacillus megaterium five mutations away from wild type is a highly active catalyst for cyclopropanation of a variety of acrylamide and acrylate olefins with ethyl diazoacetate (EDA). The very high rate of reaction enabled by histidine ligation allowed the reaction to be conducted under aerobic conditions. The promiscuity of this catalyst for a variety of substrates containing amides has enabled synthesis of a small library of precursors to levomilnacipran derivatives. This journal is

Ketene reactions with tertiary amines

Tertiary amines react rapidly and reversibly with arylketenes in acetonitrile forming observable zwitterions, and these undergo amine catalyzed dealkylation forming N,N-disubstituted amides. Reactions of N- methyldialkylamines show a strong preference for methyl group loss by displacement, as predicted by computational studies. Loss of ethyl groups in reactions with triethylamine also occur by displacement, but preferential loss of isopropyl groups in the phenylketene reaction with diisopropylethylamine evidently involves elimination. Quinuclidine rapidly forms long-lived zwitterions with arylketenes, providing a model for catalysis by cinchona and related alkaloids in stereoselective additions to ketenes.