1159183-28-4

Basic information

• Product Name: C₄₄H₄₀F₂N₂O₈
• Synonyms: C₄₄H₄₀F₂N₂O₈
• CAS NO: 1159183-28-4
• Molecular Weight: 762.807
• Mol File: 1159183-28-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₄H₄₀F₂N₂O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₄H₄₀F₂N₂O₈(1159183-28-4)
• EPA Substance Registry System: C₄₄H₄₀F₂N₂O₈(1159183-28-4)

Safety Data

• Hazardous Substances Data: 1159183-28-4(Hazardous Substances Data)

Upstream product

• 1159183-27-3 benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate 
• 1056460-25-3 (S)-3-[4-[2-(4-fluorophenyl)-[1.3]dioxan-2-yl]-1-oxobutyl]-4-phenyloxazolidin-2-one 

Downstream Products

• 1159183-31-9 C₃₅H₃₁F₂NO₆ 
• 1185883-42-4 C₄₁H₃₄F₂N₂O₇ 
• 1185883-38-8 C₄₁H₃₆F₂N₂O₇ 

Relevant articles and documents

A METHOD OF MANUFACTURING (3R,4S)-L-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3- HYDROXYPROPYL)]-4-(4-HYDROXYPHENYL)-2-AZETIDINONE AND ITS INTERMEDIATES

A method of manufacturing (3R,4S)-l-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) of formula I, in which a protected ketone of general formula II, wherein R stands for a protective group, such as benzyloxycarbonyl, tert-butoxycarbonyl, benzhydryl or trityl, is reduced with asymmetrical borane agents in an inert organic solvent in the temperature range of -30 to +40 °C, and finally the obtained protected alcohol of general formula III, wherein R has the same meaning as above, is deprotected by the action of hydro genolytic or acidic agents in an inert organic solvent.