1159183-27-3

Basic information

• Product Name: benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate
• Synonyms: benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate
• CAS NO: 1159183-27-3
• Molecular Weight: 349.361
• Mol File: 1159183-27-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate(1159183-27-3)
• EPA Substance Registry System: benzyl-[4-(4-fluorophenyliminomethyl)phenyl]-carbonate(1159183-27-3)

Safety Data

• Hazardous Substances Data: 1159183-27-3(Hazardous Substances Data)

Upstream product

• 3382-63-6 N-(4-hydroxybenzylidene)-4-fluorobenzenamine 
• 501-53-1 benzyl chloroformate 
• 371-40-4 4-fluoroaniline 
• 344252-96-6 4-formylphenyl phenylmethyl carbonate 

Downstream Products

• 1159183-28-4 C₄₄H₄₀F₂N₂O₈ 
• 1185883-38-8 C₄₁H₃₆F₂N₂O₇ 
• 1185883-42-4 C₄₁H₃₄F₂N₂O₇ 

Relevant articles and documents

INTERMEDIATES FOR THE PREPARATION OF (3R, 4S)-1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)]-4-(4-HYDROXYPHENYL)-2-AZETIDINONE

A method for the preparation of (S)-alcohol oxazolidides of general formula II, in which PG represents hydrogen or a hydroxyl protecting group, such as trimethylsilyl, tert-butyldimethylsilyl, benzyloxycarbonyl, tert-butoxycarbonyl, benzyl, benzhydryl or

A METHOD OF MANUFACTURING (3R,4S)-L-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3- HYDROXYPROPYL)]-4-(4-HYDROXYPHENYL)-2-AZETIDINONE AND ITS INTERMEDIATES

A method of manufacturing (3R,4S)-l-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3- hydroxypropyl)]-4-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) of formula I, in which a protected ketone of general formula II, wherein R stands for a protective group, such as benzyloxycarbonyl, tert-butoxycarbonyl, benzhydryl or trityl, is reduced with asymmetrical borane agents in an inert organic solvent in the temperature range of -30 to +40 °C, and finally the obtained protected alcohol of general formula III, wherein R has the same meaning as above, is deprotected by the action of hydro genolytic or acidic agents in an inert organic solvent.