1160861-53-9Relevant articles and documents
Method for synthesizing large-steric-hindrance biphenyl organic phosphine compound
-
Paragraph 0006; 0020-0021, (2020/08/09)
The invention discloses a method for synthesizing a large-steric-hindrance biphenyl organic phosphine compound, relates to a synthesis method of 2-dialkylphosphine-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl, and belongs to the field of organic synthesis. In a water-free oxygen-free atmosphere, dialkyl phosphine chloride is used as a raw material to react with magnesium to generate dialkyl phosphine magnesium chloride, and then dialkyl phosphine magnesium chloride reacts with 2-halo-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl under the action of a nickel catalyst to generate 2-dialkylphosphine-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl. Compared with the prior art, the method has the advantages of mild reaction conditions, high yield and simple post-treatment, and is suitable for industrial production.
LIGANDS FOR TRANSITION-METAL-CATALYZED CROSS-COUPLINGS, AND METHODS OF USE THEREOF
-
Page/Page column 116, (2009/07/17)
Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition-metal-catalyzed cross-coupling reactions.