116091-64-6

Basic information

• Product Name: 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
• Synonyms: 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
• CAS NO: 116091-64-6
• Molecular Weight: 384.927
• Mol File: 116091-64-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 232-236 °C
• CAS DataBase Reference: 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride(116091-64-6)
• EPA Substance Registry System: 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride(116091-64-6)

Safety Data

• Hazardous Substances Data: 116091-64-6(Hazardous Substances Data)

Usage

Uses

R,R-2-Methoxy-5-[2-(1-phenylethylamino)-propyl] Benzene Sulfonamide Hydrochloride is an impurity and metabolite of the a1-adrenergic blocking agent Tamsulosin (T006350). It is optically active.

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 116091-63-5 2-methoxy-5-(2-oxopropyl)benzenesulfonamide 

Downstream Products

• 106133-20-4 tamsulosin hydrochloride 
• 106133-20-4 (R)-tamsulosin 
• 86225-65-2 (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride 
• 622853-23-0 R,R-2-hydroxy-5-[2-(1-phenylethylamino)propyl]benzenesulfonamide 
• 112101-81-2 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide 

Relevant articles and documents

Preparation method of tamsulosin hydrochloride

The invention provides a preparation method of tamsulosin hydrochloride. Specifically, the preparation method comprises a step of reacting 5-acetonyl-2-methoxybenzenesulfonamide with (R)-1-phenylethylamine under the action of a reducing agent to obtain a compound as shown in a formula (IV) or pharmaceutically acceptable salt thereof, and further comprises a step of preparing tamsulosin hydrochloride from the compound as shown in the formula (IV) or pharmaceutically acceptable salt thereof. The preparation method provided by the invention is high in safety and strong in operability, avoids theuse of a heavy metal catalyst, and has an industrial actual use value.

Tamsulosin derivative

The optically active compound, R(?)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-hydroxybenzenesulfonamide in good optical purity, a metabolite of the α1-adrenergic blocking agent tamsulosin, and methods for the preparation thereof. Pharmaceutical compositions including the optically active compound and methods of treatment comprising administration of an effective α-adrenergic antagonistic amount of such compositions to mammals.