116114-14-8

Basic information

• Product Name: 5-(4-chlorophenyl)-4-ethyl-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
• Synonyms: 3H-1,2,4-triazol-3-one, 5-(4-chlorophenyl)-4-ethyl-2,4-dihydro-2-methyl-; 5-(4-CHLOROPHENYL)-4-ETHYL-2,4-DIHYDRO-2-METHYL-3H-1,2,4-TRIAZOL-3-ONE
• CAS NO: 116114-14-8
• Molecular Formula: C₁₁H₁₂ClN₃O
• Molecular Weight: 237.6855
• Mol File: 116114-14-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 308.1°C at 760 mmHg
• Flash Point: 140.1°C
• Density: 1.29g/cm³
• Vapor Pressure: 0.000697mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 5-(4-chlorophenyl)-4-ethyl-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-4-ethyl-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one(116114-14-8)
• EPA Substance Registry System: 5-(4-chlorophenyl)-4-ethyl-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one(116114-14-8)

Safety Data

• Hazardous Substances Data: 116114-14-8(Hazardous Substances Data)

Usage

General Description

5-(4-chlorophenyl)-4-ethyl-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one is a chemical compound with a molecular formula C11H12ClN3O. It is a powerful inhibitor of the enzyme microsomal steroidogenesis, causing a decrease in testosterone synthesis. This chemical has shown potential as a treatment for certain hormone-dependent cancers and disorders. Additionally, it has been studied for its potential use as a male contraceptive and as a tool for studying the role of testosterone in various physiological processes. However, further research is needed to fully understand its potential medical applications and to assess its safety and efficacy.

Upstream product

• 536-40-3 4-chlorobenzoic acid hydrazide 
• 116114-18-2 1-(4-Chlorobenzoyl)-4-ethylsemicarbazide 
• 31409-32-2 5-(4-Chlorophenyl)-4-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 74-88-4 methyl iodide 

Downstream Products

• 110623-26-2 5-(4-Chlorophenyl)-4-ethyl-2-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders

This invention relates to neuroprotective 5-aryl-3H-1,2,4-triazol-3-ones and to their use in the treatment of neurodegenerative disorders such as cerebral ischemia, stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.

5-phenyl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants

This invention relates to 5-phenyl-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.

The Bis(tricyclohexylstannyl) Sulfide Thionation of 3H-1,2,4-Triazol-3-ones

5-Aryl-2,4-dialkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones may be converted in 55-74percent yield to the corresponding 3H-1,2,4-triazole-3-thiones by using the combination bis(tricyclohexylstannyl) sulfide/boron trichloride.