116114-18-2Relevant articles and documents
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
Baxendale, Ian R.,Ley, Steven V.,Martinelli, Marisa
, p. 5323 - 5349 (2007/10/03)
Herein, we report on the preparation of a library of 5-substituted-2-amino- 1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products.
5-phenyl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants
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, (2008/06/13)
This invention relates to 5-phenyl-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.
Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones
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, (2008/06/13)
This invention relates to a novel process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3--thiones, useful as antidepressants, through the thionation of the corresponding 5-aryl-2,4-dialkyl-3H-1,2,4-triazol--3-ones.