1163728-92-4

Basic information

• Product Name: 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole
• Synonyms: 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole
• CAS NO: 1163728-92-4
• Molecular Weight: 297.267
• Mol File: 1163728-92-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole(1163728-92-4)
• EPA Substance Registry System: 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole(1163728-92-4)

Safety Data

• Hazardous Substances Data: 1163728-92-4(Hazardous Substances Data)

Upstream product

• 2369-29-1 3,5-difluoro-1,2-phenylenediamine 
• 27996-86-7 4-(1H-1,2,4-triazol-1-yl)benzaldehyde 

Downstream Products

• 1163729-05-2 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-(3-methylbenzyl)-4,6-difluoro-1H-benzo[d]imidazole 
• 1163728-95-7 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1-propyl-1H-benzo[d]imidazole 
• 1163728-96-8 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-allyl-4,6-difluoro-1H-benzo[d]imidazole 
• 1163728-97-9 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1-(prop-2-ynyl)-1H-benzo[d]imidazole 
• 1163729-02-9 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1-(tosyl)-1H-benzo[d]imidazole 
• 1163729-07-4 2-[4-(1H-[1,2,4]-triazol-1-yl) phenyl]-1-(2-methylbenzyl)-4,6-difluoro-1H-benzo[d]imidazole 
• 1163729-00-7 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-(3-fluorobenzyl)-4,6-difluoro-1H-benzo[d]imidazole 
• 1163729-01-8 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-(3-chlorobenzyl)-4,6-difluoro-1H-benzo[d]imidazole 
• 1163729-04-1 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-(4-fluorobenzyl)-4,6-difluoro-1H-benzo[d]imidazole 
• 1163729-06-3 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-(3-methoxybenzyl)-4,6-difluoro-1H-benzo[d]imidazole 
• 1163729-03-0 2-[4-(1H-[1,2,4]-triazol-1-yl) phenyl]-1-[3-(trifluoromethyl)-benzyl]-4,6-difluoro-1H-benzo[d]imidazole 
• 1163728-98-0 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole-1-acetonitrile 
• 1163728-93-5 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1-methyl-1H-benzo[d]imidazole 

Relevant articles and documents

SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

In the present study, a series of novel 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-substituted-4,6-difluoro-1H-benz o[d]imidazole derivatives are synthesized by the alkylation of 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole with substituted alkyl and aryl halides. The compounds were evaluated for their preliminary in-vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa and then were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. The antibacterial data suggested that the analogs with electronegative substituents emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antimycobacterials. Few of selected analogs are under further evaluation for secondary antitubercular screening, as they have shown better activity compared to rifampin.