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2369-29-1

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2369-29-1 Usage

Description

1,2-Diamino-3,5-difluorobenzene is a chemical compound with the formula C6H6F2N2. It belongs to the family of compounds called Fluorobenzenes and is also a derivative of Anilines. Its unique structure comprises a benzene ring as a backbone, with two amine (NH2) groups and two fluoride (F) atoms attached to it. 1,2-Diamino-3,5-difluorobenzene possesses a molar mass of 148.12 g/mol. It is used in various research and industrial applications, particularly in the synthesis of other complex chemical structures. Detailed information about its physical and chemical properties, toxicity, or safe handling procedures should be obtained from relevant safety data sheets (SDS).

Uses

Used in Chemical Synthesis:
1,2-Diamino-3,5-difluorobenzene is used as a building block for the synthesis of more complex chemical structures. Its unique combination of amine and fluoride groups allows for versatile reactivity in various chemical reactions, making it a valuable intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
1,2-Diamino-3,5-difluorobenzene is used as a key intermediate in the development of new pharmaceutical compounds. Its presence in the molecular structure can influence the properties of the final drug, such as solubility, stability, and bioavailability, which are crucial for the drug's effectiveness and safety.
Used in Agrochemical Industry:
1,2-Diamino-3,5-difluorobenzene is used as a starting material in the synthesis of agrochemicals, such as pesticides and herbicides. The introduction of fluorine atoms can enhance the lipophilicity and metabolic stability of these compounds, leading to improved performance in agricultural applications.
Used in Research and Development:
1,2-Diamino-3,5-difluorobenzene is used as a research compound in academic and industrial laboratories. Its unique structure and reactivity make it an interesting subject for studies in organic chemistry, materials science, and related fields, contributing to the advancement of scientific knowledge and the development of new technologies.

Check Digit Verification of cas no

The CAS Registry Mumber 2369-29-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,6 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2369-29:
(6*2)+(5*3)+(4*6)+(3*9)+(2*2)+(1*9)=91
91 % 10 = 1
So 2369-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H6F2N2/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,9-10H2

2369-29-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2-Diamino-3,5-difluorobenzene

1.2 Other means of identification

Product number -
Other names 3,5-Difluorobenzene-1,2-diamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2369-29-1 SDS

2369-29-1Relevant articles and documents

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

Gillespie, James E.,Morrill, Charlotte,Phipps, Robert J.

supporting information, p. 9355 - 9360 (2021/07/19)

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

SAR156497, an exquisitely selective inhibitor of Aurora kinases

Carry, Jean-Christophe,Clerc, Fran?ois,Minoux, Hervé,Schio, Laurent,Mauger, Jacques,Nair, Anil,Parmantier, Eric,Le Moigne, Ronan,Delorme, Cécile,Nicolas, Jean-Paul,Krick, Alain,Abécassis, Pierre-Yves,Crocq-Stuerga, Véronique,Pouzieux, Stéphanie,Delarbre, Laure,Maignan, Sébastien,Bertrand, Thomas,Bjergarde, Kirsten,Ma, Nina,Lachaud, Sylvette,Guizani, Houlfa,Lebel, Rémi,Doerflinger, Gilles,Monget, Sylvie,Perron, Sébastien,Gasse, Francis,Angouillant-Boniface, Odile,Filoche-Rommé, Bruno,Murer, Michel,Gontier, Sylvie,Prévost, Céline,Monteiro, Marie-Line,Combeau, Cécile

supporting information, p. 362 - 375 (2015/03/04)

The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small molecule Auror

SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

Jadhav, Ganesh Rajaram,Shaikh, Mohammad Usman,Kale, Rajesh Prabhakar,Shiradkar, Mahendra Ramesh,Gill, Charansingh Harnamsingh

experimental part, p. 2930 - 2935 (2009/10/02)

In the present study, a series of novel 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-1-substituted-4,6-difluoro-1H-benz o[d]imidazole derivatives are synthesized by the alkylation of 2-[4-(1H-[1,2,4]-triazol-1-yl)phenyl]-4,6-difluoro-1H-benzo[d]imidazole with substituted alkyl and aryl halides. The compounds were evaluated for their preliminary in-vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa and then were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. The antibacterial data suggested that the analogs with electronegative substituents emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antimycobacterials. Few of selected analogs are under further evaluation for secondary antitubercular screening, as they have shown better activity compared to rifampin.

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