116815-03-3

Basic information

• Product Name: 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
• Synonyms: 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;8-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;8-chloro-1,2,3,4-tetrahydro-5H-1-Benzazepin-5-one
• CAS NO: 116815-03-3
• Molecular Formula: C₁₀H₁₀ClNO
• Molecular Weight: 195.65
• Product Categories: pharmacetical
• Mol File: 116815-03-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 352.635 °C at 760 mmHg
• Flash Point: 167.068 °C
• Appearance: /
• Density: 1.235 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.18±0.20(Predicted)
• CAS DataBase Reference: 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(116815-03-3)
• EPA Substance Registry System: 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE(116815-03-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 116815-03-3(Hazardous Substances Data)

Usage

General Description

8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE is a chemical compound with the molecular formula C13H13ClNO, and a molecular weight of 239.7 g/mol. It is a white to off-white solid that is classified as a benzodiazepine derivative. 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE is mainly used in the research and development of pharmaceuticals, particularly in the study and synthesis of new psychoactive substances. The specific properties and potential uses of 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE in various applications are still being investigated and studied.

InChI:InChI=1/C10H10ClNO/c11-7-3-4-8-9(6-7)12-5-1-2-10(8)13/h3-4,6,12H,1-2,5H2

Upstream product

• 851045-58-4 2-[tert-butoxycarbonyl-(3-methoxycarbonyl-propyl)-amino]-4-chloro-benzoic acid methyl ester 
• 42087-80-9 methyl 4-chloro-2-nitrobenzoate 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 143771-90-8 8-Chloro-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester 
• 38314-47-5 methyl 4-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate 
• 29247-79-8 N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 38314-49-7 8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine 

Downstream Products

• 137984-93-1 8-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 271248-58-9 8-chloro-1-(2-methylbenzoyl)-1,2,3,4-tetrahydro-1-benzazepin-5-one 
• 38314-49-7 8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine 
• 851045-59-5 8-chloro-5-oxo-2,3,4,5-tetrahydro-benzo[b]azepine-1-carboxylic acid tert-butyl ester 
• 154890-41-2 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA

Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating artherosclerosis and its sequelae.

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.