1170669-31-4

Basic information

• Product Name: ethyl N-{(4S)-4-(benzyloxycarbonyl)-4-[(tert-butoxycarbonyl)amino]butanoyl}-N-benzyl-4-(benzylthio)isovalyl-β-alaninate
• CAS NO: 1170669-31-4
• Molecular Weight: 747.953
• Mol File: 1170669-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl N-{(4S)-4-(benzyloxycarbonyl)-4-[(tert-butoxycarbonyl)amino]butanoyl}-N-benzyl-4-(benzylthio)isovalyl-β-alaninate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-{(4S)-4-(benzyloxycarbonyl)-4-[(tert-butoxycarbonyl)amino]butanoyl}-N-benzyl-4-(benzylthio)isovalyl-β-alaninate(1170669-31-4)
• EPA Substance Registry System: ethyl N-{(4S)-4-(benzyloxycarbonyl)-4-[(tert-butoxycarbonyl)amino]butanoyl}-N-benzyl-4-(benzylthio)isovalyl-β-alaninate(1170669-31-4)

Safety Data

• Hazardous Substances Data: 1170669-31-4(Hazardous Substances Data)

Upstream product

• 2920-08-3 ethyl isocyanopropionate 
• 19360-96-4 4-benzylsulfanyl-butan-2-one 
• 30924-93-7 Boc-Glu-OBn 
• 100-46-9 benzylamine 

Relevant articles and documents

One-step synthesis of N-acetylcysteine and glutathione derivatives using the Ugi reaction

Fully protected natural and unnatural N-acetylcysteine, dipeptide Cys-Gly, glutathione, and homoglutathione derivatives were synthesized by the Ugi four-component reaction using various benzylthio aldehydes and ketones as carbonyl building blocks. The scope and limitations of the method were investigated. Formation of imidazoline by-products in the Ugi reaction was discussed. 2,2,2-Trifluoroethanol was shown to be a superior reaction media than methanol in some reactions. Also, the 4-methyl-2,6,7-trioxabicyclo[2.2.2]octyl derivative (OBO-ester) of isocyanoacetic acid was shown to be superior to use than ethyl isocyanoacetate as a peptide synthesis precursor in cases when higher reactivity of an isocyanide is required.