117370-45-3

Basic information

• Product Name: FMOC-GLY-PHE-OH
• Synonyms: FMOC-GLY-PHE-OH;FMOC-L-GLYCYL PHENYLALANINE;(S)-2-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)acetamido)-3-phenylpropanoic acid;REF DUPL: Fmoc-Gly-Phe-OH;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycyl-L-phenylalanine;Fmoc-GF-OH;Fmoc-Gly-L-Phe-OH
• CAS NO: 117370-45-3
• Molecular Formula: C₂₆H₂₄N₂O₅
• Molecular Weight: 444.48
• Mol File: 117370-45-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 739.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.298
• Storage Temp.: -15°C
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: FMOC-GLY-PHE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-GLY-PHE-OH(117370-45-3)
• EPA Substance Registry System: FMOC-GLY-PHE-OH(117370-45-3)

Safety Data

• Hazardous Substances Data: 117370-45-3(Hazardous Substances Data)

Usage

Uses

Fmoc-Gly-Phe-OH is used in the formation of nanostructured hydrogels that support the three-dimensional cell culture of chondrocytes.

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 7364-51-4 N,O-bis(trimethylsilyl)phenylalanine 
• 103321-49-9 9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate 
• 63-91-2 L-phenylalanine 
• 3321-03-7 Gly-Phe-OH 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 16874-17-2 L-phenylalanine tert-butyl ester 

Downstream Products

• 157756-66-6 (9-fluorenylmethyloxycarbonyl)glycyl-L-phenylalanine pentafluorophenyl ester 
• 903528-95-0 [(1-chlorocarbonyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 63986-20-9 HCl·H-Tyr(OH)-Gly-Gly-Phe-Leu-OH 
• 1493792-56-5 9-fluorenylmethoxycarbonyl-Gly-Phe-3-methylanilide 
• 1493792-70-3 C₂₆H₂₄N₂O₄S 
• 160617-39-0 Fmoc-Gly-Phe-Leu-OBzl 

Relevant articles and documents

RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY

Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule

Characterization of Nα-Fmoc-protected dipeptide isomers by electrospray ionization tandem mass spectrometry (ESI-MSn): Effect of protecting group on fragmentation of dipeptides

A series of positional isomeric pairs of Fmoc-protected dipeptides, Fmoc-Gly-Xxx-OY/Fmoc-Xxx-Gly-OY (Xxx = Ala, Val, Leu, Phe) and Fmoc-Ala-Xxx-OY/Fmoc-Xxx-Ala-OY (Xxx = Leu, Phe) (Fmoc = [(9-fluorenylmethyl) oxy]carbonyl) and Y = CH3/H), have been characterized and differentiated by both positive and negative ion electrospray ionization ion-trap tandem mass spectrometry (ESI-IT-MSn). In contrast to the behavior of reported unprotected dipeptide isomers which mainly produce y 1+ and/or a1+ ions, the protonated Fmoc-Xxx-Gly-OY, Fmoc-Ala-Xxx-OY and Fmoc-Xxx-Ala-OY yield significant b 1+ ions. These ions are formed, presumably with stable protonated aziridinone structures. However, the peptides with Gly- at the N-terminus do not form b1+ ions. The [M + H]+ ions of all the peptides undergo a McLafferty-type rearrangement followed by loss of CO2 to form [M + H-Fmoc + H]+. The MS3 collision-induced dissociation (CID) of these ions helps distinguish the pairs of isomeric dipeptides studied in this work. Further, negative ion MS 3 CID has also been found to be useful for differentiating these isomeric peptide acids. The MS3 of [M-H-Fmoc + H]- of isomeric peptide acids produce c1-, z1 - and y1- ions. Thus the present study of Fmoc-protected peptides provides additional information on mass spectral characterization of the dipeptides and distinguishes the positional isomers. Copyright

A mild and selective method for the cleavage of tert-butyl esters

A method for the cleavage of t-butyl esters using silica gel in refluxing toluene is reported. Good yields of the corresponding carboxylic acids are obtained, and the reaction is selective for t-butyl esters over t-butyl ethers and trimethylsilylethyl (TMSE) esters.