117483-89-3

Basic information

• Product Name: 1-[(BENZYLOXY)CARBONYL]-2-INDOLINECARBOXYLIC ACID
• Synonyms: 1-[(BENZYLOXY)CARBONYL]-2-INDOLINECARBOXYLIC ACID;BUTTPARK 95\50-74;1-[(Benzyloxy)carbonyl]-2-indolinecarboxylic acid, 90+%;1-[(Benzyloxy)carbonyl]indoline-2-carboxylic acid;2,3-Dihydro-1H-indole-1,2-dicarboxylic acid 1-benzyl ester;1-CBZ-2-indolinecarboxylic acid;1H-Indole-1,2-dicarboxylic acid, 2,3-dihydro-, 1-(phenylMethyl) ester
• CAS NO: 117483-89-3
• Molecular Formula: C₁₇H₁₅NO₄
• Molecular Weight: 297.31
• Mol File: 117483-89-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103-105°C
• Boiling Point: 499.4°Cat760mmHg
• Flash Point: 255.8°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 8.59E-11mmHg at 25°C
• Refractive Index: 1.636
• PKA: 3.85±0.20(Predicted)
• CAS DataBase Reference: 1-[(BENZYLOXY)CARBONYL]-2-INDOLINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(BENZYLOXY)CARBONYL]-2-INDOLINECARBOXYLIC ACID(117483-89-3)
• EPA Substance Registry System: 1-[(BENZYLOXY)CARBONYL]-2-INDOLINECARBOXYLIC ACID(117483-89-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 117483-89-3(Hazardous Substances Data)

Usage

Uses

1-[(Benzyloxy)carbonyl]-2-indolinecarboxylic Acid is a reagent in the preparation of dihydroisoxanzoles derivatives transglutaminase 2 enzyme inhibitor.

InChI:InChI=1/C17H15NO4/c19-16(20)15-10-13-8-4-5-9-14(13)18(15)17(21)22-11-12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,19,20)

Upstream product

• 16851-56-2 indolin-2-yl carboxylic acid 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1260502-53-1 benzyl 2-(2-amino-3-carbamoylphenylcarbamoyl)indoline-1-carboxylate 
• 1260502-39-3 benzyl 2-(4-carbamoyl-1H-benzo[d]imidazol-2-yl)indoline-1-carboxylate 
• 174666-36-5 Benzyl 2-(4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-3-ylmethylcarbamoyl)-2,3-dihydroindole-1-carboxylate 
• 205493-74-9 (3S,4S)-3-(1-N-benzyloxycarbonyl-2-indolinecarbonyl)-amino-4-acetoxy-azetidin-2-one 

Relevant articles and documents

Stereoselective synthesis of diazabicyclic β-lactams through intramolecular amination of unactivated C(sp3)-H bonds of carboxamides by palladium catalysis

An efficient C(sp3)-H bond activation and intramolecular amination reaction via palladium catalysis at the β-position of carboxyamides to make β-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the β-methylene group. Short sequences were developed for preparation of various diazabicyclic β-lactam compounds with this method as the key step from chiral proline and piperidine derivatives.

Renin inhibitors

Polypeptides of relatively low molecular weight and small size; namely derivatives of 4-amino-3-hydroxy-4--substituted butanoic acids and 5-amino-2,5-disubstituted--4-hydroxypentunoic acids for use as inhibitors of the cleavage of angiotensinogen by renin