1181267-38-8

Basic information

• Product Name: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester
• Synonyms: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester
• CAS NO: 1181267-38-8
• Molecular Weight: 477.647
• Mol File: 1181267-38-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester(1181267-38-8)
• EPA Substance Registry System: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester(1181267-38-8)

Safety Data

• Hazardous Substances Data: 1181267-38-8(Hazardous Substances Data)

Usage

Molecular structure

Complex

Functional groups

Benzimidazole group, piperidine group, ethoxyethyl group, acetic acid methyl ester group

Pharmaceutical properties

Likely due to benzimidazole group (anti-parasitic, anti-ulcer properties) and piperidine group (analgesic, anesthetic effects)

Potential therapeutic applications

May have therapeutic properties, further study and testing needed

Upstream product

• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 1000536-33-3 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester 
• 1181267-32-2 methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate 
• 110963-63-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole 
• 1181267-36-6 tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 1298022-54-4 methyl 2-methyl-2-(4-vinylphenyl)propanoate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 154825-97-5 methyl 2-(4-bromophenyl)-2,2-dimethylacetate 
• 547-63-7 Methyl isobutyrate 
• 1567835-74-8 2-(1-(4-bromophenethyl)piperidin-4-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole 
• 1841081-72-8 1-(2-ethoxyethyl)-2-piperidin-4-yl-1H-benzimidazole hydrochloride 
• 1181267-30-0 methyl 2-methyl-2-(4-{2-[(4-methylbenzenesulfonyl)oxy]ethyl}phenyl)propanoate 
• 57625-74-8 methyl 2-methyl-2-phenylpropionate 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 202189-78-4 Bilastine 

Relevant articles and documents

Preparation method of bilastine key intermediate

The invention belongs to the technical field of drug synthesis, and relates to 2 - (4 - (2 - (4 -ethoxyethyl) 1 - benzo [2 -] imidazol - 1H - yl) piperi d-ethyl) phenyl) -2 -methylpropionate (-1 -), and a -2 - complex and II acid are used as a catalyst to condensation the enolate anion with the compound (16 15) to form a target product II Ni Lewis. The invention aims to provide a short synthetic route. The provided route raw material condition is mild, the yield is high, the tedious building quaternary carbon atom method reported in the traditional process is avoided, and the method is suitable for industrial production.

Preparation process of bilastine

The invention belongs to the technical field of medicines, and particularly relates to a preparation process of bilastine. According to the process, esterification, deprotection, iodination and hydrolysis reactions are conducted to generate bilastine. The

Preparation method and application of bilastine

The invention provides a preparation method and application of bilastine. Bilastine is prepared by: subjecting methyl 2-methyl-2-{4-[2-(toluene-4-sulfonyloxy)-ethyl]-phenyl}-propionate as an initial material to condensation synthesis with 1-(2-ethoxy-2-et