118207-34-4Relevant articles and documents
The effect of different amine bases in the Swern oxidation of β-amino alcohols
Chrisman, William,Singaram, Bakthan
, p. 2053 - 2056 (1997)
Swern oxidation of β-amino alcohols containing tertiary amino groups afforded the corresponding α-amino carbonyl compounds in fair to excellent yield. Yields were dependent on the steric requirement of the amine base used for the reaction and were optimiz
Dynamic kinetic resolution allows a highly enantioselective synthesis of cis-α-aminocycloalkanols by ruthenium-catalyzed asymmetric hydrogenation
Liu, Sheng,Xie, Jian-Hua,Wang, Li-Xin,Zhou, Qi-Lin
, p. 7506 - 7508 (2008/09/17)
(Chemical Equation Presented) Resolutely dynamic hydrogenation: A highly efficient asymmetric hydrogenation of racemic N,N-disubstituted α-aminocycloalkanones involving dynamic kinetic resolution in the presence of a ruthenium catalyst gives chiral α-aminocycloalkanols with excellent enantioselectivities and cis diastereoselectivities (see scheme). A synthesis of optically pure U-(-)-50488 based on this reaction is reported.
Synthesis and Receptor Binding of Enantiomeric N-Substituted cis-N--2-(1-pyrrolidinyl)cyclohexylamines as High-Affinity ? Receptor Ligands
Radesca, Lilian,Bowen, Wayne D.,Paolo, Lisa Di,Costa, Brian R. de
, p. 3058 - 3065 (2007/10/02)
N-Alkyl-substituted derivatives of (+)- and (-)-cis-N--2-(1-pyrrolidinyl)cyclohexylamine have been synthesized in nine steps in a stereospecific manner starting from cyclohexene oxide.The key step in the reaction sequence invo
