1183013-69-5

Basic information

• Product Name: 2-Amino-2-(3-bromophenyl)propan-1-ol
• Synonyms: 2-Amino-2-(3-bromophenyl)propan-1-ol
• CAS NO: 1183013-69-5
• Molecular Weight: 230.104
• Mol File: 1183013-69-5.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 2-Amino-2-(3-bromophenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-2-(3-bromophenyl)propan-1-ol(1183013-69-5)
• EPA Substance Registry System: 2-Amino-2-(3-bromophenyl)propan-1-ol(1183013-69-5)

Safety Data

• Hazardous Substances Data: 1183013-69-5(Hazardous Substances Data)

Usage

Derivative

It is derived from phenylpropanolamine, an amphetamine derivative.

Function

Used as a decongestant and appetite suppressant.

Chemical Structure

Contains a bromine atom and an amino group attached to a propanol structure.

Chemical Similarity

Chemically similar to other amphetamines.

Potential Uses

Considered a potential drug precursor.

Psychoactive Effects

May have psychoactive effects, although not extensively studied.

Handling Caution

Caution should be taken when handling and using due to potential harmful effects if ingested or inhaled.

Upstream product

• 7399-36-2 rac-2-amino-2-(3-bromophenyl)-propionic acid 
• 6943-33-5 (RS)-5-(3-bromo-phenyl)-5-methyl-imidazolidine-2,4-dione 
• 1262858-65-0 (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid hydrochloride 
• 1183581-39-6 (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester 

Downstream Products

• 1262858-66-1 rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide 
• 1266784-00-2 (RS)-5-[3-(benzhydrylidene-amino)-phenyl]-5-methyl-morpholin-3-one 
• 1266784-04-6 (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266784-05-7 (S)-(-)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266784-94-4 (RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine 
• 1369542-55-1 rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide 
• 1397683-42-9 (R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione 
• 1397683-41-8 (R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one 
• 1397683-39-4 (R)-6-(3-bromo-phenyl)-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one 
• 1397683-34-9 2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester 
• 1213181-85-1 (2R)-2-amino-2-(3-bromophenyl)-propan-1-ol 
• 1213052-82-4 (2S)-2-amino-2-(3-bromophenyl)-propan-1-ol 
• 887913-70-4 rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide 
• 887913-71-5 rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2,2-dioxide 

Relevant articles and documents

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360

Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6-position of the 5-amino-1,4-oxazine, the insertion of a Me and a CF3 group delivered an excellent pharmacological profile wi

5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES

The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are

4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.