1183581-39-6

Basic information

• Product Name: (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester
• Synonyms: (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester
• CAS NO: 1183581-39-6
• Molecular Weight: 258.115
• Mol File: 1183581-39-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester(1183581-39-6)
• EPA Substance Registry System: (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester(1183581-39-6)

Safety Data

• Hazardous Substances Data: 1183581-39-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 953741-63-4 rac-2-amino-2-(3-bromo-phenyl)-propionitrile 
• 64-19-7 acetic acid 
• 6943-33-5 (RS)-5-(3-bromo-phenyl)-5-methyl-imidazolidine-2,4-dione 
• 7399-36-2 rac-2-amino-2-(3-bromophenyl)-propionic acid 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 1262858-65-0 (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid hydrochloride 

Downstream Products

• 1183013-69-5 (RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol 
• 1266784-00-2 (RS)-5-[3-(benzhydrylidene-amino)-phenyl]-5-methyl-morpholin-3-one 
• 1266784-04-6 (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266784-05-7 (S)-(-)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide 
• 1266784-94-4 (RS)-[5-(3-amino-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine 
• 1352126-35-2 2-(3-bromophenyl)-2-(2-chloroacetylamino)propionic acid methyl ester 
• 1352126-36-3 3-(3-bromophenyl)-1,3-dimethylpiperazine-2,5-dione 
• 1352126-37-4 rac-1,3-dimethyl-3-(3-pyrimidin-5-yl-phenyl)piperazine-2,5-dione 
• 1352126-38-5 rac-1,3-dimethyl-3-(3-pyrimidin-5-ylphenyl)-5-thioxopiperazine-2-one 
• 1352126-39-6 rac-3-(3-bromophenyl)-5-methoxy-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1352126-40-9 rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 
• 1352126-41-0 rac-3-(3-bromophenyl)-1,3-dimethyl-5-thioxopiperazine-2-one 
• 1352126-31-8 rac-5-amino-1,3-dimethyl-3-(3-pyrimidin-5-yl-phenyl)-3,6-dihydro-1H-pyrazin-2-one 
• 1352126-32-9 rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one 

Relevant articles and documents

5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES

The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are

4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.

5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS

The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.