1183623-74-6

Basic information

• Product Name: 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde
• Synonyms: 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde
• CAS NO: 1183623-74-6
• Molecular Weight: 204.204
• Mol File: 1183623-74-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde(1183623-74-6)
• EPA Substance Registry System: 2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzaldehyde(1183623-74-6)

Safety Data

• Hazardous Substances Data: 1183623-74-6(Hazardous Substances Data)

Upstream product

• 699016-40-5 2-fluoro-4-iodobenzaldehyde 
• 761446-44-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 847818-55-7 (1-methyl-1H-pyrazol-4-yl)boronic acid 
• 1418201-67-8 4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole 
• 188582-62-9 4-bromo-2-fluorobenzyl alcohol 

Downstream Products

• 1432436-23-1 N-(1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 1432436-20-8 N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzylidene)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

A Palladium-Catalyzed Double Carbonylation Approach to Isatins from 2-Iodoanilines

A high-yielding procedure for the synthesis of isatins has been developed. Sequential Pd-catalyzed double carbonylation of 2-iodoanilines with near stoichiometric amounts of CO followed by acid-promoted cyclization readily affords an array of isatins. The conversion of 2-iodoanilines to isatins in good to excellent yields was found to proceed with good functional group tolerance. This protocol proved adaptable to 13C-isotope labeling of isatins, which was extended to the synthesis of the 13C-isotope labeled antiviral drug metisazone and the experimental anti-schizophrenia drug ML137.

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.