118917-59-2

Basic information

• Product Name: Benzenesulfonamide, N-(2-hydroxy-1-phenylethyl)-4-methyl-, (R)-
• CAS NO: 118917-59-2
• Molecular Formula: C15H17NO3S
• Molecular Weight: 291.371
• Mol File: 118917-59-2.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(2-hydroxy-1-phenylethyl)-4-methyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(2-hydroxy-1-phenylethyl)-4-methyl-, (R)-(118917-59-2)
• EPA Substance Registry System: Benzenesulfonamide, N-(2-hydroxy-1-phenylethyl)-4-methyl-, (R)-(118917-59-2)

Safety Data

• Hazardous Substances Data: 118917-59-2(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 60712-47-2 (R)-2-((4-methylphenyl)sulfonamido)-2-phenylacetic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 875-74-1 (R)-phenylglycine 
• 5660-63-9 4,4,5,5-tetramethyl-1,3-dioxolane 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 124-38-9 carbon dioxide 
• 56613-80-0 D-2-phenylglycinol 
• 127-65-1 chloroamine-T 
• 111047-53-1 (R)-2-phenylglycine methyl ester hydrochloride salt 
• 6485-63-8 ethyl 2-(4-methylphenylsulfonamido)-2-phenylacetate 
• 70-55-3 toluene-4-sulfonamide 
• 20989-17-7 Phenylglycinol 

Downstream Products

• 193482-24-5 N-(R)-(2-acetoxy-1-phenylethyl)-p-toluenesulfonamide 
• 161977-37-3 (2S,4R)-2-Methyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidine-2-carbonitrile 
• 161977-38-4 (2S,4R)-2-Ethyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidine-2-carbonitrile 
• 161977-39-5 [(2S,4R)-2-Methyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-phenyl-methanone 
• 161977-40-8 [(2S,4R)-2-Ethyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-phenyl-methanone 
• 161977-47-5 (R)-1-[(2S,4R)-2-Ethyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-1-phenyl-ethanol 
• 161977-43-1 (R)-1-[(2S,4R)-2-Methyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-1,2-diphenyl-ethanol 
• 1393751-17-1 (R)-N-allyl-N-(2-hydroxy-1-phenylethyl)-4-methylbenzenesulfonamide 
• 1393751-27-3 4-methyl-N-(((2R,5R)-5-phenyl-4-tosylmorpholin-2-yl)methyl)benzenesulfonamide 
• 1393751-28-4 4-methyl-N-(((2S,5R)-5-phenyl-4-tosylmorpholin-2-yl)methyl)benzenesulfonamide 

Relevant articles and documents

A tandem process for the synthesis of β-aminoboronic acids from aziridines with haloamine intermediates

An unprecedented synthetic strategy is devised to generate β-aminoboronic acids from aziridines via a sequential process involving 1,2-iodoamine formation and radical borylation under light irradiation. A variety of aziridines including multiply substituted aziridines have been successfully employed as synthetic precursors, expanding their synthetic utility compared to previous methods. Mechanistic studies suggest that the boron source plays a unique role in the borylation step, and in the formation of haloamine intermediates.

Pd(ii)-Catalyzed aerobic 1,2-difunctionalization of conjugated dienes: Efficient synthesis of morpholines and 2-morpholones

A novel and efficient methodology concerning the Pd(ii)-catalyzed intermolecular difunctionalization of conjugated dienes is reported to synthesize a series of functionalized morpholines and 2-morpholones. Widely distributed and easily obtained β-amino alcohols and α-amino acids, as starting nitrogen and oxygen sources, are successfully applied in the difunctionalization of conjugated dienes respectively. The majority of the desired products were obtained in moderate to excellent yields. Oxygen was successfully employed as a terminal oxidant. Further transformation of the generated products allowed for the expansion of structural diversity.

Cis -1,2-Aminohydroxylation of Alkenes Involving a Catalytic Cycle of Osmium(III) and Osmium(V) Centers: OsV(O)(NHTs) Active Oxidant with a Macrocyclic Tetradentate Ligand

Catalytic activity of [OsIII(OH)(H2O)(L-N4Me2)](PF6)2 (1: L-N4Me2 = N,N′-dimethyl-2,11-diaza-[3,3](2,6)pyridinophane) in 1,2-cis-aminohydroxylation of alkenes with sodium N-chloro-4-methylbenzenesulfonamide (chloramine-T) is explored. Simple alkenes as well as those containing several types of substituents are converted to the corresponding 1,2-aminoalcohols in modest to high yields. The aminoalcohol products have exclusively cis conformation with respect to the introduced -OH and -NHTs groups. The spectroscopic measurements including cold mass spectroscopic study of the reaction product of complex 1 and chloromine-T as well as density functional theory (DFT) calculations indicate that an oxido-aminato-osmium(V) species [OsV(O)(NHTs)(L-N4Me2)](PF6)2 (2) is an active oxidant for the aminohydroxylation. The DFT calculations further indicate that the reaction involves a [3 + 2] cycloaddition between 2 and alkene, and the regioselectivity in the aminohydroxylation of unsymmetrical alkenes is determined by the orientation that bears less steric hindrance from the tosylamino group, which leads to the energetically more preferred product isomer.