119-34-6 Usage
Description
4-Amino-2-nitrophenol is a dark red crystalline or reddish-purple solid, characterized by its dark brown fine crystalline powder appearance. It has a melting point of 125-127°C and is known for its use in the hair dye industry.
Uses
Used in Hair Dye Industry:
4-Amino-2-nitrophenol is used as a semipermanent (nonoxidative) hair colorant and toner for both human hair and animal fur. It is particularly effective in semipermanent hair dyes, where it provides color without the need for oxidation. The typical concentration in these hair dyes is estimated to be on the order of 0.1–1.0%.
Used in Analytical Chemistry:
4-Amino-2-nitrophenol is also utilized in the determination of aminonitrophenols in hair dyes through differential pulse voltammetry and high-performance liquid chromatography (HPLC) with electrochemical detection. This application is crucial for ensuring the safety and quality of hair dye products in the market.
Air & Water Reactions
Sensitive to oxidation upon prolonged exposure to air. Insoluble in water.
Reactivity Profile
4-Amino-2-nitrophenol may react with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .
Fire Hazard
Flash point data for 4-Amino-2-nitrophenol are not available. 4-Amino-2-nitrophenol is probably combustible.
Safety Profile
Suspected carcinogen
with experimental carcinogenic data. Very
poisonous by intraperitoneal route.
Moderately toxic by ingestion. A severe eye heated to decomposition it emits toxic
fumes of NOx.
Potential Exposure
In dye formulation for furs and hair
Carcinogenicity
Under the conditions of the bioassay, the compound was
carcinogenic in male rats inducing transitional cell carcinomas
of the urinary bladder (controls 0/15, lowdose 0/46, high
dose 11/39). The same tumor was also observed in three
dosed female rats and may have been associated with the
administration of the chemical. No evidence of carcinogenic
activity was found in the mice.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. It is unknown if this nitro compound is explosive; some are flammable and explosive, and the contact with alkali increases thermal sensitivity of these materials.
Check Digit Verification of cas no
The CAS Registry Mumber 119-34-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 119-34:
(5*1)+(4*1)+(3*9)+(2*3)+(1*4)=46
46 % 10 = 6
So 119-34-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N2O3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H,7H2
119-34-6Relevant articles and documents
Magnetically Recoverable Gold Nanorods as a Novel Catalyst for the Facile Reduction of Nitroarenes Under Aqueous Conditions
Lamei, Kamran,Eshghi, Hossein,Bakavoli, Mehdi,Rostamnia, Sadegh
, p. 491 - 501 (2017)
Abstract: In this work, cysteine-functionalized Fe3O4@Carbon magnetic nanoparticles were used for the synthesis of gold nanorods. Fe3O4@C nanoparticles were first prepared by synthesis of Fe3O4magnetic nanoparticles (MNPs), and then carbon-coated MNPs (Fe3O4@C) were synthesized by glucose carbonization using a hydrothermal method. Finally, the gold NRs were loaded on the modified surface of Fe3O4@C MNPs. The designed magnetically recoverable gold nanorods, after full characterization by FTIR, SEM, TEM, TGA, VSM, XRD, and ICP-OES, were applied to the reduction of nitroarenes. The Fe3O4@C@Cys–Au nanorods showed higher performance than Fe3O4@C@Cys–Au nanospheres in a selective facile reduction of nitroarenes to the corresponding aminoarenes in aqueous medium at room temperature using NaBH4. Graphical Abstract: [Figure not available: see fulltext.]
Preparation method for osimertinib mesylate
-
Paragraph 0013; 0014, (2018/04/28)
The invention discloses a preparation method for osimertinib mesylate. The chemical name of osimertinib mesylate is N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide mesylate (AZD9291), and the chemical formula is C28H33N7O2.CH4O3S. The process of the preparation technique of the preparation method is simple, materials areeasy to obtain, and the preparation method is cost-efficient and environment-friendly, can help realize industrialization, can promote the economic and technological development of osimertinib activeingredients, reduces production cost, and is suitable for mass production.
Vanadium pentoxide as a catalyst for regioselective nitration of organic compounds under conventional and nonconventional conditions
Venkatesham,Reddy, K. Rajendar,Rajanna,Veerasomaiah
, p. 921 - 926 (2014/04/03)
Vanadium pentoxide is used as an efficient catalyst for regioselective nitration of aromatic compounds under conventional and nonconventional conditions such as ultrasonically assisted (USAR) and microwave-assisted reactions (MWAR). The reactions underwent smoothly and afforded good yields of products with high regioselectivity. Observed longer reaction times (about 8 h) in V2O5 catalyzed reactions reduced to (0.5/30 min) under sonication and (90 s) in the case of MWAR. When ortho position is blocked, para derivatives are obtained as end products while ortho nitro products are obtained when para position is blocked.